File:Cajal bodies PMID12379800.jpg

Nucleus - Cajal Bodies

Located within the cell nucleus these bodies have also been called: nucleolar accessory bodies, coiled body, gems. Their size is about 0.1 - 2.0 microns, numbering about 1 to 10 in each nucleus. Proposed sites where small nuclear ribonucleoproteins (snRNPs) and small nucleolar RNAs (snoRNPs) are modified.

Ramón y Cajal first identified and christened them "nucleolar accessory bodies". PMID 14685175

Recently the Fragile X protein (FMRP) isoforms 6 and 12 (ISO6 and 12) were localized to the Cajal bodies in cultured human cells. PMID 24204304

• A - HeLa cells expressing an FP–coilin fusion protein (arrows indicate Cajal bodies).
• B - Fluorescence micrograph of purified CBs immunolabeled with anticoilin antibodies.
• C - Field emission scanning electron micrograph of a purified CB.
• D - Transmission electron micrograph of a purified CB. Coilin is immunolabeled with 5 nm gold (arrows) and SMN is immunolabeled with 10 nm gold (arrowheads).

Bars: (A and B) 10 μm; (C) 500 nm; (D) 200 nm.

Links: Image - FMRP and Cahal bodies | Cajal | Fragile X Syndrome | Search PubMed

Reference

<pubmed>12379800</pubmed>| PMC2173504 | J Cell Biol.

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Figure 1. relabelled and resized.