File:Limb induction-initiation signal 02.jpg
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Molecular Mechanisms of Limb Bud Formation
Study demonstrates the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.
A - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LPM.
B - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expres- sion. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
- Links: image - summary | image - signal interaction | Retinoic acid | Tbx
Reference
<pubmed>26212321</pubmed>
Copyright
Copyright © 2015 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Figure 7. resized and labeled with PMID.
Cite this page: Hill, M.A. (2026, October 4) Embryology Limb induction-initiation signal 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Limb_induction-initiation_signal_02.jpg
- © Dr Mark Hill 2026, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G[
(C and D) Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).
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| current | 14:13, 13 September 2016 | | 1,280 × 1,009 (124 KB) | Z8600021 (talk | contribs) | Figure 7. The Molecular Mechanisms of Limb Bud Formation (A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LP... |
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