File:Implantation cartoon 02.jpg
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Key Molecules for Decidualization
Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid).
Decidualization involves coordination of several processes, including polyploidy, and several types of molecules, such as cytokine receptors, enzymes, morphogens, hormones and transcription factors.
Legend
ADM, adrenomedullin; BV, blood vessel; DEDD, death effector domain–containing protein; IL-11Rα, interleukin 11 receptor α; mTORC1, mammalian target of rapamycin complex 1; SGK1, serum- and glucocorticoid-inducible kinase 1; Sphk1/2, sphingosine kinase 1/2.
Reference
<pubmed>PMID 23223073</pubmed>| Nat Med
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)
Nm.3012-F2.jpg
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:47, 18 March 2013 | | 950 × 1,000 (161 KB) | Z8600021 (talk | contribs) | Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid). Decidualizatio... |
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