Talk:Musculoskeletal System - Tendon Development: Difference between revisions
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PMID 15634692 | PMID 15634692 | ||
==Tendon Development== | |||
===Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development=== | |||
Development. 2005 Feb;132(3):515-28. Epub 2005 Jan 5. | |||
Brent AE, Braun T, Tabin CJ. | |||
Source | |||
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. | |||
Abstract | |||
Proper formation of the musculoskeletal system requires the coordinated development of the muscle, cartilage and tendon lineages arising from the somitic mesoderm. During early somite development, muscle and cartilage emerge from two distinct compartments, the myotome and sclerotome, in response to signals secreted from surrounding tissues. As the somite matures, the tendon lineage is established within the dorsolateral sclerotome, adjacent to and beneath the myotome. We examine interactions between the three lineages by observing tendon development in mouse mutants with genetically disrupted muscle or cartilage development. Through analysis of embryos carrying null mutations in Myf5 and Myod1, hence lacking both muscle progenitors and differentiated muscle, we identify an essential role for the specified myotome in axial tendon development, and suggest that absence of tendon formation in Myf5/Myod1 mutants results from loss of the myotomal FGF proteins, which depend upon Myf5 and Myod1 for their expression, and are required, in turn, for induction of the tendon progenitor markers. Our analysis of Sox5/Sox6 double mutants, in which the chondroprogenitors are unable to differentiate into cartilage, reveals that the two cell fates arising from the sclerotome, axial tendon and cartilage are alternative lineages, and that cartilage differentiation is required to actively repress tendon development in the dorsolateral sclerotome. | |||
PMID: 15634692 | |||
http://www.ncbi.nlm.nih.gov/pubmed/15634692 | |||
==2003== | |||
===Welcome to syndetome: a new somitic compartment=== | |||
Dev Cell. 2003 May;4(5):611-2. | |||
Dubrulle J, Pourquie O. | |||
Source | |||
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. | |||
Abstract | |||
Virtually nothing was known about the embryonic origin of tendons, until a recent paper by Brent and colleagues in which they track the origin of tendon progenitors of the body axis and reveal the molecular events and tissue interactions leading to their commitment. | |||
Comment on | |||
Cell. 2003 Apr 18;113(2):235-48. | |||
PMID: 12737797 | |||
===A somitic compartment of tendon progenitors=== | |||
Cell. 2003 Apr 18;113(2):235-48. | |||
Brent AE, Schweitzer R, Tabin CJ. | |||
Source | |||
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. | |||
Abstract | |||
We demonstrate that the tendons associated with the axial skeleton derive from a heretofore unappreciated, fourth compartment of the somites. Scleraxis (Scx), a bHLH transcription factor, marks this somitic tendon progenitor population at its inception, and is continuously expressed through differentiation into the mature tendons. Two earlier-formed somitic compartments, the sclerotome and myotome, interact to establish this fourth Scx-positive compartment. The tendon progenitors are induced at the sclerotome's edge, at the expense of skeletogenic Pax1 positive cells and in response to FGF signaling in the adjacent myotome. The tendon primordia thus form in a location abutting the two tissues that the mature tendons must ultimately connect. Tendon progenitor formation may reveal a general mechanism for the specification of other somitic subcompartments. | |||
Comment in | |||
Dev Cell. 2003 May;4(5):611-2. | |||
PMID 12705871 | |||
Revision as of 13:22, 6 September 2011
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Glossary Links
Cite this page: Hill, M.A. (2024, June 11) Embryology Musculoskeletal System - Tendon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Musculoskeletal_System_-_Tendon_Development |
2005
Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
Development. 2005 Feb;132(3):515-28. Epub 2005 Jan 5.
Brent AE, Braun T, Tabin CJ. Source Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Abstract
Proper formation of the musculoskeletal system requires the coordinated development of the muscle, cartilage and tendon lineages arising from the somitic mesoderm. During early somite development, muscle and cartilage emerge from two distinct compartments, the myotome and sclerotome, in response to signals secreted from surrounding tissues. As the somite matures, the tendon lineage is established within the dorsolateral sclerotome, adjacent to and beneath the myotome. We examine interactions between the three lineages by observing tendon development in mouse mutants with genetically disrupted muscle or cartilage development. Through analysis of embryos carrying null mutations in Myf5 and Myod1, hence lacking both muscle progenitors and differentiated muscle, we identify an essential role for the specified myotome in axial tendon development, and suggest that absence of tendon formation in Myf5/Myod1 mutants results from loss of the myotomal FGF proteins, which depend upon Myf5 and Myod1 for their expression, and are required, in turn, for induction of the tendon progenitor markers. Our analysis of Sox5/Sox6 double mutants, in which the chondroprogenitors are unable to differentiate into cartilage, reveals that the two cell fates arising from the sclerotome, axial tendon and cartilage are alternative lineages, and that cartilage differentiation is required to actively repress tendon development in the dorsolateral sclerotome.
PMID 15634692
Tendon Development
Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
Development. 2005 Feb;132(3):515-28. Epub 2005 Jan 5.
Brent AE, Braun T, Tabin CJ. Source Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Abstract
Proper formation of the musculoskeletal system requires the coordinated development of the muscle, cartilage and tendon lineages arising from the somitic mesoderm. During early somite development, muscle and cartilage emerge from two distinct compartments, the myotome and sclerotome, in response to signals secreted from surrounding tissues. As the somite matures, the tendon lineage is established within the dorsolateral sclerotome, adjacent to and beneath the myotome. We examine interactions between the three lineages by observing tendon development in mouse mutants with genetically disrupted muscle or cartilage development. Through analysis of embryos carrying null mutations in Myf5 and Myod1, hence lacking both muscle progenitors and differentiated muscle, we identify an essential role for the specified myotome in axial tendon development, and suggest that absence of tendon formation in Myf5/Myod1 mutants results from loss of the myotomal FGF proteins, which depend upon Myf5 and Myod1 for their expression, and are required, in turn, for induction of the tendon progenitor markers. Our analysis of Sox5/Sox6 double mutants, in which the chondroprogenitors are unable to differentiate into cartilage, reveals that the two cell fates arising from the sclerotome, axial tendon and cartilage are alternative lineages, and that cartilage differentiation is required to actively repress tendon development in the dorsolateral sclerotome.
PMID: 15634692 http://www.ncbi.nlm.nih.gov/pubmed/15634692
2003
Welcome to syndetome: a new somitic compartment
Dev Cell. 2003 May;4(5):611-2.
Dubrulle J, Pourquie O. Source Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. Abstract Virtually nothing was known about the embryonic origin of tendons, until a recent paper by Brent and colleagues in which they track the origin of tendon progenitors of the body axis and reveal the molecular events and tissue interactions leading to their commitment.
Comment on Cell. 2003 Apr 18;113(2):235-48. PMID: 12737797
A somitic compartment of tendon progenitors
Cell. 2003 Apr 18;113(2):235-48.
Brent AE, Schweitzer R, Tabin CJ. Source Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Abstract
We demonstrate that the tendons associated with the axial skeleton derive from a heretofore unappreciated, fourth compartment of the somites. Scleraxis (Scx), a bHLH transcription factor, marks this somitic tendon progenitor population at its inception, and is continuously expressed through differentiation into the mature tendons. Two earlier-formed somitic compartments, the sclerotome and myotome, interact to establish this fourth Scx-positive compartment. The tendon progenitors are induced at the sclerotome's edge, at the expense of skeletogenic Pax1 positive cells and in response to FGF signaling in the adjacent myotome. The tendon primordia thus form in a location abutting the two tissues that the mature tendons must ultimately connect. Tendon progenitor formation may reveal a general mechanism for the specification of other somitic subcompartments.
Comment in Dev Cell. 2003 May;4(5):611-2.
PMID 12705871
