Talk:Placenta - Cord

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On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes: References - recent and historic that relates to the topic Additional topic information - currently prepared in draft format Links - to related webpages Topic page - an edit history as used on other Wiki sites Lecture/Practical - student feedback Student Projects - online project discussions. Links: Pubmed Most Recent | Reference Tutorial | Journal Searches Glossary Links Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link Cite this page: Hill, M.A. (2026, October 16) Embryology Placenta - Cord. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Placenta_-_Cord

2007

Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis

Seval Y, Korgun ET, Demir R. Placenta. 2007 Aug-Sep;28(8-9):841-5. Epub 2007 Mar 9.

The stroma of the placental villi contain numerous macrophages, so-called Hofbauer cells which are of mesenchymal origin and are thought to function in many processes. Although there are many studies concerning placental vasculogenesis and angiogenesis, there has been a lack of evidence on the possible roles of Hofbauer cells in these processes. In this study we hypothesized that Hofbauer cell locations and numbers might be correlated with the vascular structures within the placental villi core and therefore may be implicated to play roles in placental vasculogenesis and angiogenesis. Placental tissues were obtained from normal first-trimester pregnancies. Tissues were prepared for light microscopic investigations. Double immunohistochemistry staining with CD31/PECAM1 and CD68 was applied to placental tissues. In placental villous core, majority of the Hofbauer cells were found to be either in close contact with angiogenic cell cords and primitive vascular tubes or located in between them. Moreover, the number of Hofbauer cells and vasculogenic structures were found to be significantly correlated. The findings of this study suggest for the first time that Hofbauer cells might be involved in the processes of vasculogenesis and angiogenesis in the placenta.

PMID: 17350092 http://www.ncbi.nlm.nih.gov/pubmed/17350092

2005

Embryogenesis of fused umbilical arteries in human embryos

Am J Obstet Gynecol. 2005 Nov;193(5):1709-15.

Yamada S, Hamanishi J, Tanada S, Tachibana M, Mimura R, Fujii S, Shiota K. Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan. shyamada@cac.med.kyoto-u.ac.jp

Abstract

OBJECTIVE: The objective of this study was to elucidate the embryologic basis of fused umbilical arteries in the human.

STUDY DESIGN: Twenty-nine human embryo specimens at Carnegie stages 11 through 15 (4-5 weeks after fertilization) were examined histologically, with special reference to the development of umbilical arteries.

RESULTS: All embryos at Carnegie stage 11 and 12 had fused umbilical arteries, and 66% of Carnegie stage 13 embryos and 29% of Carnegie stage 14 embryos still had the condition. None of the embryos at Carnegie stage 15 or older had fused umbilical arteries, but there were always 2 arteries present in their umbilical cords. CONCLUSION: Our data suggest that (1) a single umbilical artery splits into 2 as the developmental stage of the embryo advances, (2) that fused umbilical arteries represent a remnant of the embryonic phenotype, and (3) that fused umbilical arteries are embryologically distinct from true single umbilical artery.

PMID: 16260215 http://www.ncbi.nlm.nih.gov/pubmed/16260215

1989

Isolation and characterization of Hofbauer cells from human placental villi

Arch Gynecol Obstet. 1989;246(4):189-200.

Zaccheo D, Pistoia V, Castellucci M, Martinoli C.

Istituto di Anatomia Umana Normale, Università di Genova, Italy. Abstract Hofbauer cells are a major cell type of the human placental villous core and they are particularly numerous at the beginning of pregnancy. In the present study we describe a method suitable to obtain HC suspensions in a highly purified form. These suspensions have been analyzed for surface markers using a battery of monoclonal antibodies. Of all the surface markers used, Hofbauer cells were only positive for 4F2, LeuM2 and LeuM3 monoclonals which mainly detect cells of the monocyte-macrophage lineage. Hofbauer cells were consistently negative for HLA-DR antigens, C3bR and T- or B-cell markers. Hofbauer cells appeared capable of phagocytosing latex beads, adhering to and spreading over plastic surface and secreting lysozyme. In contrast, they failed to originate an efficient respiratory burst in response to appropriate stimulation. Hofbauer cells were positive for ANAE with a perinuclear localization of the enzyme activity, but consistently negative for peroxidase. These observations suggest that they share a number of features with cells of the monocyte-macrophage lineage and yet have some distinctive properties.

PMID: 2482706