Developmental Mechanism - Cell Junctions: Difference between revisions

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Embryology - 23 Aug 2026 Expand to Translate
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Introduction

Many developmental mechanisms require dynamic changes in cell adhesion that acts through different types of cell junctions.

Adhesion Cartoons

Tight junction
Adherens Junction
Desmosome
Gap Junction

Adhesion EM Images

GIT epithelia EM1
GIT epithelia EM2
GIT epithelia EM3
Desmosome EM

Adhesion EM Images: GIT epithelia EM1 | GIT epithelia EM2 | GIT epithelia EM3 | Desmosome EM

Adhesion Cartoons: Tight junction | Adherens Junction | Desmosome | Gap Junction

Tight Junction

Discovered by M.G. Farquhar and G.E. Palade in 1963
zonula occludens
Fusion of 2 plasma membranes acts as a “seal”
Epithelia lining
digestive system gut, ducts, cavities of glands, liver, pancreas capillary walls urinary bladder

Tight junction

Adherens Junction

actin microfilaments anchor the plaque that occurs under the membrane of each cell
plaques not as dense also occur as hemi-form
heart muscle, layers covering body organs, digestive tract
transmembrane proteins
Cadherin
clustered as focal adhesion

Cadherin isoform naming was based upon the site of original identification: P-cadherin (placenta cadherin, cadherin 3), E-cadherin (epithelial cadherin cadherin 1), N-cadherin (neural cadherin, cadherin 2).

Adherens Junction

image - blood–testis barrier

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Glossary Links

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Cite this page: Hill, M.A. (2026, August 23) Embryology Developmental Mechanism - Cell Junctions. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Cell_Junctions

What Links Here?

@@ Line 38: / Line 38: @@
 Tight junction
 |}
+==Adherens Junction==
+{|
+|
+*
+* actin microfilaments anchor the plaque that occurs under the membrane of each cell
+* plaques not as dense also occur as hemi-form
+* heart muscle, layers covering body organs, digestive tract
+* transmembrane proteins
+* Cadherin
+* clustered as focal adhesion
+Cadherin isoform naming was based upon the site of original identification: P-cadherin (placenta cadherin, [https://www.omim.org/entry/114021 cadherin 3]), E-cadherin (epithelial cadherin [https://www.omim.org/entry/192090 cadherin 1]), N-cadherin (neural cadherin, [https://www.omim.org/entry/114020 cadherin 2]).
+| [[File:Adherens Junction 01.jpg|300px]]
+Adherens Junction
+|}
+[[:File:Rat blood–testis barrier 02.jpg|image - blood–testis barrier]]
 ==External Links==