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Revision as of 20:21, 17 August 2015
Function of BMP signaling during satellite cell differentiation
Quiescent satellite cells (green) do not respond to BMP signals. Upon activation, satellite cells express MyoD and respond to BMP signals with phosphorylation of p-Smad (red) and reduced differentiation.
After satellite cell descendents are committed to differentiate (yellow) they express Myogenin and subsequently the BMP inhibitor Chordin.
Upon inhibition of BMP signaling, myoblasts exit the cell cycle, fuse into myotubes and undergo terminal differentiation (purple).
Postmitotic myonuclei (blue) irreversibly loose the competence to respond to BMP signals.
Figure 10
Reference
<pubmed>21645366</pubmed>PMC3149017
Copyright
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original file name: 1471-2121-12-26-10.jpg
Cite this page: Hill, M.A. (2024, June 26) Embryology Model BMP satellite cell differentiation.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_BMP_satellite_cell_differentiation.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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