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(==The Hippo Pathway and its mode of action== * '''A''' - When the Hippo pathway is ON, MST1/2 phosphorylate SAV1 and together they phosphorylate and activate MOB1A/B and LATS1/2, which then phosphorylate YAP and TAZ. Phosphorylated YAP and TAZ are se...)
 
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==The Hippo Pathway and its mode of action==
==Fly WT dorsal view head thorax SEM==


*  '''A''' - When the Hippo pathway is ON, MST1/2 phosphorylate SAV1 and together they phosphorylate and activate MOB1A/B and LATS1/2, which then phosphorylate YAP and TAZ. Phosphorylated YAP and TAZ are sequestered in the cytoplasm by the 14-3-3 phosphopeptide binding proteins and shunted for proteasomal degradation. As a result, the TEAD transcription factors associate with VGL4 and suppress target gene expression.
* '''B''' - When the Hippo pathway is OFF, the MST1/2 and LATS1/2 kinases are inactive, YAP and TAZ are not phosphorylated and accumulate in the nucleus where they displace VGL4 and complex with TEADs. YAP and TAZ are transcriptional co-activators and in complex with TEADs promote the expression of target genes.


 
:'''Links:''' [[Fly Development]] | [[Developmental Signals - Hippo]] | [[Scanning Electron Microscopy]]
:'''Links:''' [[Developmental Signals - Hippo]]





Revision as of 10:53, 11 June 2015

Fly WT dorsal view head thorax SEM

Links: Fly Development | Developmental Signals - Hippo | Scanning Electron Microscopy


Reference

<pubmed>24336504</pubmed>| Nat Rev Drug Discov.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nature Reviews Drug Discovery (Randy Johnson, Georg Halder The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov: 2014, 13(1);63-79), copyright (2015)

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current10:51, 11 June 2015Thumbnail for version as of 10:51, 11 June 2015555 × 796 (95 KB)Z8600021 (talk | contribs)==The Hippo Pathway and its mode of action== * '''A''' - When the Hippo pathway is ON, MST1/2 phosphorylate SAV1 and together they phosphorylate and activate MOB1A/B and LATS1/2, which then phosphorylate YAP and TAZ. Phosphorylated YAP and TAZ are se...

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