File:Notch structure cartoon.jpg: Difference between revisions
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==Notch Structure cartoon== | ==Notch Structure cartoon== | ||
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The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). | | The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). | ||
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* gray ovals - N-terminal 36 EGF-like repeats | * gray ovals - N-terminal 36 EGF-like repeats | ||
* orange ovals - lin-12 Notch | * orange ovals - (LNR) lin-12 Notch | ||
* pink ovals - EGF repeats | * pink ovals - EGF repeats | ||
* gray rectangles - ankyrin (ANK) domain | * gray rectangles - ankyrin (ANK) domain | ||
* gray star - C-terminal PEST sequence | * gray star - C-terminal PEST sequence | ||
* red arrows - cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). | * red arrows - cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). | ||
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{{Notch links}} | {{Notch links}} |
Revision as of 06:41, 11 February 2015
Notch Structure cartoon
The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). |
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- Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
Reference
<pubmed>19255248</pubmed>
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current | 20:49, 4 February 2015 | 1,093 × 227 (35 KB) | Z8600021 (talk | contribs) | ==Notch Structure cartoon== The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an... |
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