File:Implantation cartoon 01.jpg: Difference between revisions
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'''Legend''' | '''Legend''' | ||
{| | |||
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* '''AA''' - arachidonic acid | * '''AA''' - arachidonic acid | ||
* '''BMP2''' - bone morphogenetic protein 2 | * '''BMP2''' - bone morphogenetic protein 2 | ||
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* '''ENaC''' - epithelium sodium channel | * '''ENaC''' - epithelium sodium channel | ||
* '''ER''' - estrogen receptor | * '''ER''' - estrogen receptor | ||
* '''ErbB1/4 | | | ||
* '''ErbB1/4''' - epidermal growth factor receptor 1/4 | |||
* '''ERK''' - extracellular signal–regulated kinase | * '''ERK''' - extracellular signal–regulated kinase | ||
* '''FGF''' - fibroblast growth factor | * '''FGF''' - fibroblast growth factor | ||
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* '''Hoxa10/11''' - homeobox A10/11 | * '''Hoxa10/11''' - homeobox A10/11 | ||
* '''ICM''' - inner cell mass | * '''ICM''' - inner cell mass | ||
| | |||
* '''IHH''' - Indian hedgehog | * '''IHH''' - Indian hedgehog | ||
* '''KLF5''' - Kruppel-like factor 5 | * '''KLF5''' - Kruppel-like factor 5 | ||
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* '''P4''' - progesterone | * '''P4''' - progesterone | ||
* '''PG''' - prostaglandin | * '''PG''' - prostaglandin | ||
* '''PPAR-δ | * '''PPAR-δ''' - peroxisome proliferators–activating receptor δ | ||
* '''PR''' - progesterone receptor | * '''PR''' - progesterone receptor | ||
* '''Ptc''' - Patched | * '''Ptc''' - Patched |
Revision as of 14:44, 17 March 2014
Molecular Implantation Cartoon
This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown.
Legend
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Compartment colours
Reference<pubmed>23223073</pubmed>| Nat Med CopyrightReprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012) Nm.3012-F1.jpg |
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current | 17:46, 18 March 2013 | 1,000 × 756 (154 KB) | Z8600021 (talk | contribs) | This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian... |
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