File:Mouse Brain E17 MRI 01.jpg: Difference between revisions

Mouse Brain E17 Magnetic Resonance Microscopy

Magnetic resonance microscopy (MRM) enables concurrent visualization of the brain and face of E17 mouse foetuses.

• A - Forebrain regions, pituitary, and cerebellum were manually segmented from transverse 39 µm MRM sections.
• B - 3D brain reconstructions were generated by overlaying manually segmented regions with whole-brain masks.
• C,D - Reduced opacity of the left cortex and diencephalon allows visualization of the left ventricle, hippocampus, third ventricle, and pituitary. From the same MRM scans, 3D head reconstructions were created, allowing concurrent visualization of the face and brain in situ.
• E - The size of a GD17 mouse fetus can be appreciated when shown in scale with a U.S. penny.

Links: neural | Magnetic Resonance Imaging | mouse

Reference

Lipinski RJ, Holloway HT, O'Leary-Moore SK, Ament JJ, Pecevich SJ, Cofer GP, Budin F, Everson JL, Johnson GA & Sulik KK. (2014). Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. PLoS ONE , 9, e102603. PMID: 25047453 DOI.

Copyright

© 2014 Lipinski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 1. doi:10.1371/journal.pone.0102603.g001 Adjusted in size and labelling.