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The Female Endocrine Hypothalamic–Pituitary–Gonadal (HPG) Axis

Hypothalamus

• The hypothalamus produces and secretes gonadotrophin-releasing hormone (GnRH) into a system of blood vessels that link the hypothalamus and the pituitary gland.
• GnRH stimulates the pituitary gland by attaching to specific molecules (receptors).

Pituitary

• After the coupling of GnRH with these receptors, a cascade of biochemical events causes the pituitary gland to produce and secrete two hormones, luteinizing hormone (LH) and follicle–stimulating hormone (FSH).
• LH and FSH are two of a class of hormones commonly known as gonadotropins. They are secreted into the general vascular circulation and attach to receptors on the ovary.

Ovary

• LH and FSH in the general circulation attach to receptors on the ovary.
• They trigger ovulation and stimulate ovarian production of the hormones estrogen and progesterone.
• These female hormones cause monthly menstrual cycling and have multiple effects throughout the body.
• In particular, estrogen has profound effects on the skeletal system and is crucial to maintaining normal bone health (Kanis 1994).

Reference

<pubmed>12875037</pubmed>| NIAAA

Copyright

Most of the information available on the NIAAA Web site is within the public domain, and unless otherwise noted, may be freely downloaded and reproduced. Citation of the source is appreciated.

Original file name: Figure 1 http://pubs.niaaa.nih.gov/publications/arh26-4/274-281.htm (gonadotrophin-releasing hormone was labeled LHRH, luteinizing hormone–releasing hormone in this original figure)