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==Domoic acid== | ==Domoic acid== | ||
A marine toxin domoic acid (DA) is produced by the cosmopolitan diatom species ''Pseudonitzchia'' and known to form harmful algal blooms. The toxin has been shown to affect numerous organisms in the wild through trophic transfer including: sea birds, manatees, dolphins, sea lions, as well as humans. In human causes the illness amnesic shellfish poisoning. | |||
* acts as excitotoxin that binds to kainate subtypes of ionotropic glutamate receptors as a high affinity partial agonist that prevents normal channel inactivation. | |||
* behavioral effects of DA exposure, such as scratching, ataxia, tremors, and seizures. | |||
* identified as potential cause of cause fatal loss in stranded pregnant sea lions. | |||
* single injection into maternal rat led to detectable levels in amniotic fluid and embryonic brain tissue within 1 hour. | |||
:Links: [[Abnormal_Development_-_Chemicals | :Links: [[Abnormal Development - Biological Toxins|Biological Toxins]] | [[Abnormal_Development_-_Chemicals|Chemicals]] | [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282253 Pubchem - CID 5282253] | ||
===Reference=== | |||
<pubmed>18087593</pubmed>| [http://ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.10446 Environ Health Perspect.] | |||
Latest revision as of 10:35, 5 November 2011
Domoic acid
A marine toxin domoic acid (DA) is produced by the cosmopolitan diatom species Pseudonitzchia and known to form harmful algal blooms. The toxin has been shown to affect numerous organisms in the wild through trophic transfer including: sea birds, manatees, dolphins, sea lions, as well as humans. In human causes the illness amnesic shellfish poisoning.
- acts as excitotoxin that binds to kainate subtypes of ionotropic glutamate receptors as a high affinity partial agonist that prevents normal channel inactivation.
- behavioral effects of DA exposure, such as scratching, ataxia, tremors, and seizures.
- identified as potential cause of cause fatal loss in stranded pregnant sea lions.
- single injection into maternal rat led to detectable levels in amniotic fluid and embryonic brain tissue within 1 hour.
- Links: Biological Toxins | Chemicals | Pubchem - CID 5282253
Reference
<pubmed>18087593</pubmed>| Environ Health Perspect.
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