File:Implantation cartoon 02.jpg: Difference between revisions

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Key Molecules for Decidualization

Legend

Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid).

Decidualization involves coordination of several processes, including polyploidy, and several types of molecules, such as cytokine receptors, enzymes, morphogens, hormones and transcription factors.

ADM - adrenomedullin
BV - blood vessel
DEDD - death effector domain–containing protein
IL-11Rα - interleukin 11 receptor α
mTORC1 - mammalian target of rapamycin complex 1
SGK1 - serum- and glucocorticoid-inducible kinase 1
Sphk1/2 - sphingosine kinase 1/2

Adrenomedullin - secreted by both decidual and trophoblast cells, angiogenic and natriuretic factor both promoting growth.

Links: Implantation | Week 2

Reference

Cha J, Sun X & Dey SK. (2012). Mechanisms of implantation: strategies for successful pregnancy. Nat. Med. , 18, 1754-67. PMID: 23223073 DOI.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)

Nm.3012-F2.jpg

Cite this page: Hill, M.A. (2024, June 1) Embryology Implantation cartoon 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Implantation_cartoon_02.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	17:47, 18 March 2013		950 × 1,000 (161 KB)	Z8600021 (talk \| contribs)	Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid). Decidualizatio...

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+==Key Molecules for Decidualization==
-Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid). Decidualization involves coordination of several processes, including polyploidy, and several types of molecules, such as cytokine receptors, enzymes, morphogens, hormones and transcription factors. ADM, adrenomedullin; BV, blood vessel; DEDD, death effector domain–containing protein; IL-11Rα, interleukin 11 receptor α; mTORC1, mammalian target of rapamycin complex 1; SGK1, serum- and glucocorticoid-inducible kinase 1; Sphk1/2, sphingosine kinase 1/2.
+{|
+|
+! Legend
+|-
+| Key molecules for decidualization are depicted in this hybrid cartoon as gathered from mouse and human studies. The decidua is composed of differentiated stromal (decidual) cells, many of which are terminally differentiated (polyploid).
+Decidualization involves coordination of several processes, including polyploidy, and several types of molecules, such as cytokine receptors, enzymes, morphogens, hormones and transcription factors.
+| valign=top width=400px|
+* '''ADM''' - adrenomedullin
+* '''BV''' - blood vessel
+* '''DEDD''' - death effector domain–containing protein
+* '''IL-11Rα''' - interleukin 11 receptor α
+* '''mTORC1''' - mammalian target of rapamycin complex 1
+* '''SGK1''' - serum- and glucocorticoid-inducible kinase 1
+* '''Sphk1/2''' - sphingosine kinase 1/2
+|}
+Adrenomedullin - secreted by both decidual and trophoblast cells, angiogenic and natriuretic factor both promoting growth.
+:'''Links:''' [[Implantation]] | [[Week 2]]
+===Reference===
+{{#pmid:23223073}}
+====Copyright====
+Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy.
+Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)
 Nm.3012-F2.jpg
+{{footer}}
+[[Category:Implantation]] [[Category:Molecular]] [[Category:Cartoon]] [[Category:Week 2]]