File:Schwann and axon interactions.jpg: Difference between revisions

Revision as of 12:42, 24 September 2010

Model of interactions between myelinating Schwann cells and axons

Showing proteins that localize to the node, paranode, juxtaparanode, and internode.
Schwann cell, blue; axon, yellow. PN, paranode; JPN, juxtaparanode.

Analysis of the Necl proteins provides important new insight into molecular complexes along the internode (Maurel et al., 2007; Spiegel et al., 2007), which had not been as well defined as for the other domains.

The polarity protein Par-3 colocalizes with Necl-4 in the adaxonal region of the Schwann cell (Chan et al., 2006), and it is possible that these proteins interact via PDZ and PDZ-binding motifs (red). The Necl proteins can also interact with FERM domain proteins via the FERM-binding domain (blue). Necls are also present at the Schmidt-Lanterman incisures (inset). Necl-2 is not depicted but localizes to the axon–Schwann cell interface and to the incisures.

The figure was adapted from Voas et al. (2007).

http://jcb.rupress.org/content/178/5/721/F1.large.jpg

Reference

<pubmed>17724116</pubmed>| PMC2064536 | JCB

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current	12:41, 24 September 2010		1,280 × 807 (196 KB)	S8600021 (talk \| contribs)	==Model of interactions between myelinating Schwann cells and axons== Showing proteins that localize to the node, paranode, juxtaparanode, and internode. Schwann cell, blue; axon, yellow. PN, paranode; JPN, juxtaparanode. Analysis of the Necl proteins pr

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Neural Crest - Schwann Cell Development

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 ==Model of interactions between myelinating Schwann cells and axons==
+* Showing proteins that localize to the node, paranode, juxtaparanode, and internode.
+* Schwann cell, blue; axon, yellow. PN, paranode; JPN, juxtaparanode.
-Showing proteins that localize to the node, paranode, juxtaparanode, and internode. Schwann cell, blue; axon, yellow. PN, paranode; JPN, juxtaparanode. Analysis of the Necl proteins provides important new insight into molecular complexes along the internode (Maurel et al., 2007; Spiegel et al., 2007), which had not been as well defined as for the other domains. The polarity protein Par-3 colocalizes with Necl-4 in the adaxonal region of the Schwann cell (Chan et al., 2006), and it is possible that these proteins interact via PDZ and PDZ-binding motifs (red). The Necl proteins can also interact with FERM domain proteins via the FERM-binding domain (blue). Necls are also present at the Schmidt-Lanterman incisures (inset). Necl-2 is not depicted but localizes to the axon–Schwann cell interface and to the incisures. The figure was adapted from Voas et al. (2007).
+Analysis of the Necl proteins provides important new insight into molecular complexes along the internode (Maurel et al., 2007; Spiegel et al., 2007), which had not been as well defined as for the other domains.
+The polarity protein Par-3 colocalizes with Necl-4 in the adaxonal region of the Schwann cell (Chan et al., 2006), and it is possible that these proteins interact via PDZ and PDZ-binding motifs (red). The Necl proteins can also interact with FERM domain proteins via the FERM-binding domain (blue). Necls are also present at the Schmidt-Lanterman incisures (inset). Necl-2 is not depicted but localizes to the axon–Schwann cell interface and to the incisures.
+The figure was adapted from Voas et al. (2007).
 http://jcb.rupress.org/content/178/5/721/F1.large.jpg