File talk:Hertig1956 table1.jpg

Table 1
Ovum Numbers	Streeter Horizon	Estimated Age of Ovum (days)	Probable Day of Cycle on which ovulation occurred	Probable Day of cycle on which fertile coitus occurred	Range of EOT	Range in onset of Catamenia	Day of Cycle on which Operation occurred	Histologic "Dating" or Pattern of Endometrium	Age of Patient	No. of Labor	No. Abortions	Previous Publication References
8698	II Segmenting egg 2 cells	1.5-2.5	12-13	12*	9-15	25-27	13	17	42
8904	II 12 ± cells	3	16	15 or 17	7-18	23-30	20	18	35
8794	III Free blastocyst 58 cells	4	13	12	8-14	24-26	17	19	40
8663	III 107 cells	4.5	22	22	18-25	34-37	27	22	38
8225	Va Ovum implanted but avillous. Solid trophoblast	7	14	14*	8-18	24-30	22	21	30
8020	Va	7	17	16*	12-20	28-32	24	Earliest progestational change	38
8155	Va	8	13	12 or 13	12-16	28	22	Earliest progestational hyperplasia	29
8215	Vb Beginning lacunae	9	46	45 or 46	11-43	27-55	56	Earliest progestational hyperplasia	30
8171	Vb	9	13	12	11-18	27-30	23	Earliest progestational hyperplasia	38
8004	Vb	9	15	15	15-22	31-34	25	Moderate progestational hyperplasia	29
7699	Vc Lacunae well-formed, extra-coelomic cavity present	11	14	12	10-17	26-29	25	Moderate progestational hyperplasia	34
7950	Vc	12	14	13*	11-21	27-33	26	Moderate progestational hyperplasia	31
7700	Vc	12	17	15*	17-22	33-34	29	Advanced progestational hyperplasia	34
8558	Vc	12	13	12 or 13	11-23	27-33	25	Advanced progestational hyperplasia	38
8330	Vc	12	11	10	7-14	23-26	23	Advanced progestational hyperplasia	31
Carnegie Embryo	Vc	12	16	15	13-17	29	29	Advanced progestational hyperplasia	32
8672	VI Primitive villi, distinct yolk-sac	13	12	12*	11-23	27-35	25	Advanced progestational hyperplasia	33
8360	VI	13	15	14	10-18	26-30	28	Early decidua	33
7801	VI	13	14	14	8-16	24-28	28	Early decidua	33
7802	VII Branching villi, axis of germ disc defined	16	17	16	10-21	26-33	33	Early decidua	37
8602	VII	17	11	11	13-17	29	28	Early decidua	34
The microscopic pattern of the endometrium during the last 14 days (postovulatory or progestational phase) of any menstrual cycle follows a regular identifiable histologic sequence of events. The "dating" for each of these postovulatory days conirms to what is termed a “standard cycle" with ovulation on day 14 and menstruation on day 28. Coital date reported from memory, accuracy questionable? This ovum was fixed in acetone for histochemistry (see MSS. page 448) and has not been given an accession number at the Carnegie Laboratory. Because of the different fixation technique, its measurements are not included in table 3. In a few instances where the catamenial history was insufficient, the range in onset of catamenia was widened arbitrarily afford a longer potential ovulation time. Catamenia or a period "Periods are 28 days apart." Obviously this patient ovulated somewhat earlier than the EOT of 13-17 in order to have roduced a 17-day ovum on day 28 of the cycle. Therefore she must have ovulated about day 11.
Tables as Images: table 1 | table 2 | table 3 | table 4 | 1956 Hertig Rock Reference: Hertig AT. Rock J. and Adams EC. A description of 34 human ova within the first 17 days of development. (1956) Amer. J Anat., 98:435-493.

Ovum Numbers	Streeter Horizon	Estimated Age of Ovum (days)	Probable Day of Cycle on which ovulation occurred	Probable Day of cycle on which fertile coitus occurred	Range of EOT	Range in onset of Catamenia	Day of Cycle on which Operation occurred	Histologic "Dating" or Pattern of Endometrium	Age of Patient	No. of Labor	No. Abortions	Previous Publication References
8698	II Segmenting egg 2 cells	1.5-2.5	12-13	12*	9-15	25-27	13	17	42
8904	II 12 ± cells	3	16	15 or 17	7-18	23-30	20	18	35
8794	III Free blastocyst 58 cells	4	13	12	8-14	24-26	17	19	40
8663	III 107 cells	4.5	22	22	18-25	34-37	27	22	38
8225	Va Ovum implanted but avillous. Solid trophoblast	7	14	14*	8-18	24-30	22	21	30
8020	Va	7	17	16*	12-20	28-32	24	Earliest progestational change	38
8155	Va	8	13	12 or 13	12-16	28	22	Earliest progestational hyperplasia	29
8215	Vb Beginning lacunae	9	46	45 or 46	11-43	27-55	56	Earliest progestational hyperplasia	30
8171	Vb	9	13	12	11-18	27-30	23	Earliest progestational hyperplasia	38
8004	Vb	9	15	15	15-22	31-34	25	Moderate progestational hyperplasia	29
7699	Vc Lacunae well-formed, extra-coelomic cavity present	11	14	12	10-17	26-29	25	Moderate progestational hyperplasia	34
7950	Vc	12	14	13*	11-21	27-33	26	Moderate progestational hyperplasia	31
7700	Vc	12	17	15*	17-22	33-34	29	Advanced progestational hyperplasia	34
8558	Vc	12	13	12 or 13	11-23	27-33	25	Advanced progestational hyperplasia	38
8330	Vc	12	11	10	7-14	23-26	23	Advanced progestational hyperplasia	31
Carnegie Embryo	Vc	12	16	15	13-17	29	29	Advanced progestational hyperplasia	32
8672	VI Primitive villi, distinct yolk-sac	13	12	12*	11-23	27-35	25	Advanced progestational hyperplasia	33
8360	VI	13	15	14	10-18	26-30	28	Early decidua	33
7801	VI	13	14	14	8-16	24-28	28	Early decidua	33
7802	VII Branching villi, axis of germ disc defined	16	17	16	10-21	26-33	33	Early decidua	37
8602	VII	17	11	11	13-17	29	28	Early decidua	34

• The microscopic pattern of the endometrium during the last 14 days (postovulatory or progestational phase) of any menstrual cycle follows a regular identifiable histologic sequence of events. The "dating" for each of these postovulatory days conirms to what is termed a “standard cycle" with ovulation on day 14 and menstruation on day 28.
• Coital date reported from memory, accuracy questionable?
• This ovum was fixed in acetone for histochemistry (see MSS. page 448) and has not been given an accession number at the Carnegie Laboratory. Because of the different fixation technique, its measurements are not included in table 3.
• In a few instances where the catamenial history was insufficient, the range in onset of catamenia was widened arbitrarily afford a longer potential ovulation time.
• "Periods are 28 days apart." Obviously this patient ovulated somewhat earlier than the EOT of 13-17 in order to have roduced a 17-day ovum on day 28 of the cycle. Therefore she must have ovulated about day 11.

PROBABLE PROBABLE . , DAY OF ESTIMATED DAY on CYCLE DA‘ OF C‘ OLE RANGE IN CYCLE Ob OVUM STREETER , , ON WHICH RANGE OF N ,M AGE 01‘ ON W H101-I FERTILE 3 ONSET or WHICH L BE“ HORIZON OVUM ovULAT1oN Corpus EM‘ CATAMENIA OPERATIO OCCURRED 1 OCCURRED 9 OCCURREI days C-8698 II 1%—2§ 12-13 12* 9-15 25-27 15 S—49—2439 Segmenting egg 2 cells

C-8904 I1 3 16 15 or 17 7-18 23-30 20 S-51-2689 12 : cells

C-8794 III 4 13 12 8-14 24-26 7 17 S-50-2976 Free blastocyst

58 cells

@8663 III 4; 22 22 18-25 34-37 27 S48-5000 107 cells

C-8225 Va 7 14 14* 8-18 24-30 22 S-44-37 Ovum implanted but

avillous. Solid trophoblast

C-8020 Va 7 17 16* 12-20 28-32 24 S~42-908

($8155 Va 8 13 12 or 13 12-16 28 22 S-43-763

C-8215 Vb 9 46 45 or 46 11-43 27-55 56 S-43-2435 Beginning lacunae

C-8171 Vb 9 13 12"’ ll—18 27-30 23 S-43-1098

C-8004 Vb 9 15 15 15-22 31-347 25 S-42-672

C-7699 Vc 11 14 12 10-17 26-29 25 039-161 Lecunae well«forme(l.

Exocaelomic cavity present

C-7950 Vc 12 14 13* 11-21 27-33 26 S-41-2500

C~7700 V(‘ 12 17 15* 17-22 33-34 29 S—38-2655

C—8558 Va 12 13 12 01-13 11-23 27-35 ‘.35 S-47-2767

C-8330 V0 12 11 10 7-14 23-26 23 S«45«1823

C“ Va 12 16 15 13-17 2.0 29 S-54-3305

C-8672 V1 13 12 12* 1l-23 27-33 25 S-49-930 Primitive villi,

distinct yolk-sac

C-8360 VI 13 15 14 10-18 26-30 28 S-46-481

C-7801 VI 13 14 @145 8-16 24-28 28 S-40-1461

C-7802 B VII 11 16 17 16 10-21 26-33 S-40-1524 ranching vi i,

axis of germ disc defined

C-8602 VII 17 11 11 13-17 295 28 S-48-2088

1 Probable day of ovulation is at best an estimate based upon (a) the apparent developmental age of ovum, (b) the

terpretation of the degree of progestational change of the endoznetrium and ((5) the clinical history.

'-' Of the Coifial dates recorded by the patient the One giVen is most likely to have resulted in the pregnancy here descril;

A well isolated or single, and therefore, critical coital date. 7‘ Estimated ovulation time is based on the fact that the modal time of ovulation is 14 i 2 days before the next expec period, as follows:

25-27, range in onset of catamenia. 16-7172, range in ovulation 9-15, E.O.T. in this patient Normal fertilizer? ova of 2-17 days of development

HISTOLOGIO "DATING" OR AGE 01' N0. N0. PATTERN or PATIENT LABORS ABORTIONS PREVIOUS ""BI"C""”°N REEEEEECES

ENDOMETRIUM 4

17 42 3 0 Hertig and Rock ('51); Hertig, Rock, Mulligan, Pemberton and Adams ('52); Hertig, Rock, Adams and Mulligan ('54). 18 35 3 O Hertig, Rock, Adams and Mulligan ('54). 19 40 5 O I-Iertig‘, Rock, Mulligan, Pemberton and Adams ('52); Hertig, Rock, Adams and Mulligan ('54). 19 38 9 3 Hertig and Rock ('49, '51): Hertig, Rock. Mulligan. Pemberton and Adams ('52); Hortig, Rock, Adams and Mulligan ('54). 22 30 4 0 Hertig ('45); I-Iertig and Rock ('45a, '51). 21 38 9 1 Hertiz ('45) ; Hertig‘ and Rock ('43a, '44a, '45c, '51) ; Rock and Hertig ('42, '44, '48). Earliest 29 5 2 Hertig ('45); Hertig and Rock (‘44b, '49a, '51). progestational change Early 30 6 0 Hertig ('45); Hertig and Rock ('45b, '51). progestational hyperplasia Early 38 5 0 Hertig ('45); Hertig and Rock ('44c, '49a, '51). progestational hyperplasia Moderate 29 6 0 I-Iertig ('45); Hertig and Rock ('43h, '44a, '45c, '51); Rock and Hertig progestational ('42, '44, '48). hyperplasia Moderate 34 3 1 ‘Hertiz ('45); Hertig and Rock ('41, '42a. '44a, '51); Rock and Hertig progestational ('42, '44). hyperplasia Moderate 31 4 0 Hertig and Rock ('42a, '44a); Rock and Hertig ('42, '44, '48). progestational hyperplasia. Advanced 34 9 1 Hertig ('45); I-Iertig and Rock ('39, '41, '4-411, '49b, '50, '51); Rock progestational and I-Iertig ('42, '44). hyperplasia Advanced 38 6 0 None progestational hyperplasia Advanced 31 2 0 None progestational hype:-plaia Advanced 32 6 0 None progestational hyperplasia Advanced 33 4 2 None progestational hypcrplasia Early 33 5 1 None decidua. Early 33 7 2 I-Iertig ('45); Hertigr: and Rock ('44a, '51); Heuser, Rock and Hertig decidua ('45); Rock and Hertig ('42, '44, '48). Early 37 9 0 I-Iertig ('45); Hertig and Rock ('44a, '49b, '50, '51); Heuser, Rock decidun, and Hertig ('45); Rock and I-Iertig ('42. '44, '48). Early 34 3 0 None decidua

‘The microscopic pattern of the endometrium during the last 14 days (potovulatory or progestational phase) of any men.rual cycle follows a regular identifiable histologic sequence of events. The "dating" for each of these postovulatory days conirms to what is termed a “standard cycle" with ovulation on day 14 and menstruation on day 28.

5 Coital date reported from memory, accuracy questionable? This ovum was fixed in acetone for histochemistry (see MSS. page 448) and has not been given an accession number at Le Carnegie Laboratory. Because of the different fixation technique, its measurements are not included in table 3.

7 In a few instances where the catamenial history was insufficient, the range in onset of catamenia was widened arbitrarily

» afford a longer potential ovulation time. , 3 “Periods are 28 days apart." Obviously this patient ovulated somewhat earlier than the E01‘ of 13-17 l!l order to have

reduced a 17-day ovum on day 28 of the cycle. Therefore she must have ovulated about day 11.