File:Notch structure cartoon.jpg: Difference between revisions
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| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). | | The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). | ||
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* gray ovals - N-terminal 36 EGF-like repeats | * gray ovals - N-terminal 36 EGF-like repeats | ||
* orange ovals - (LNR) lin-12 Notch | * orange ovals - (LNR) lin-12 Notch | ||
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{{JCB}} | {{JCB}} | ||
{{Footer}} | |||
[[Category:Notch]] [[Category:Molecular]] [[Category:Pattern]] | [[Category:Notch]] [[Category:Molecular]] [[Category:Pattern]] | ||
[[Category:Developmental Signal]] | [[Category:Developmental Signal]] | ||
Latest revision as of 14:49, 31 August 2016
Notch Structure cartoon
| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase). |
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- Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
Reference
<pubmed>19255248</pubmed>
Copyright
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Cite this page: Hill, M.A. (2026, October 24) Embryology Notch structure cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Notch_structure_cartoon.jpg
- © Dr Mark Hill 2026, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| current | 21:49, 4 February 2015 |  | 1,093 × 227 (35 KB) | Z8600021 (talk | contribs) | ==Notch Structure cartoon== The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an... |
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