Template:Mitochondrial Disorders Table: Difference between revisions
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| Onset in early life | | Onset in early life | ||
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| Fatal infantile encephalopathy (Leigh syndrome) | | Fatal infantile encephalopathy<br>(Leigh syndrome) | ||
| Brain and nervous system dysfunctions | | Brain and nervous system dysfunctions | ||
| Very rare | | Very rare | ||
| Onset in infancy. Death in early childhood | | Onset in infancy. Death in early childhood | ||
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:'''Links:''' [[Mitochondria]] | [[Abnormal_Development_-_Genetic|Genetic Abnormalities]] | [[Zygote]] | :'''Links:''' [[Mitochondria]] | [[Abnormal_Development_-_Genetic|Genetic Abnormalities]] | [[Zygote]] | ||
| colspan=2|Table based on Annex D, [https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/285251/mitochondrial_donation_consultation_document_24_02_14_Accessible_V0.4.pdf UK Mitochondrial Donation 2014]. | |||
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<noinclude>[[Category:Template]][[Category:Mitochondria]][[Category:Table]][[Category:Abnormal Development]]</noinclude> | <noinclude>[[Category:Template]][[Category:Mitochondria]][[Category:Table]][[Category:Abnormal Development]]</noinclude> |
Latest revision as of 10:07, 12 February 2015
Mitochondrial DNA disorder | Description | Prevalence | Life expectancy/morbidity |
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Kearns–Sayre syndrome | Progressive blindness and blocked heart | Rare disease | Onset before 15 |
Chronic progressive external opthalmoplegia (CPEO) | Progressive wastage of eyelids, eyes and sometimes facial muscles | Rare disease | Onset in young adulthood |
Pearson syndrome | Anaemia, pancreatic failure, muscle wastage | Very rare (less than 100 worldwide) | Early death |
Myopathy, encephalopathy, lactic acidosis and stroke (MELAS) | Stroke like episodes; muscle spasm; early dementia | Rare disease | Death before 40 |
Myoclonic epilepsy and ragged-red fibres (MERFF) | Epilepsy, hearing loss, lactic acidosis, short stature | 1 in 400,000 across Europe | Childhood onset |
Neurogenic weakness, ataxia and retinitis pigmentosa (NARP) | Muscle weakness, vision loss, learning disabilities | Rare disease | Onset in early childhood. Early death |
Maternally inherited Leigh syndrome (MILS) | Muscle weakness, heart and kidney failure, delayed development | Very rare | Onset in infancy. Death in early childhood |
Maternally inherited diabetes and deafness (MIDD) | Combination of all types of diabetes with deafness | Rare disease | Adult onset |
Leber hereditary optic neuropathy (LHON) | Rapid blindness | 1 in 30,000 across Europe | Range from early childhood to 70s |
Myopathy and diabetes | Covers forms of muscular dystrophy | From infancy. Early death | |
Sensorineural hearing loss | Covers a range of hearing loss through to deafness | Common condition but rarely caused by mitochondrial disease | Onset at any age |
Exercise intolerance | Range from lethargy to muscle wastage | 1 in 8,000 but symptoms often combine with others | Onset in early life |
Fatal infantile encephalopathy (Leigh syndrome) |
Brain and nervous system dysfunctions | Very rare | Onset in infancy. Death in early childhood |
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Table based on Annex D, UK Mitochondrial Donation 2014. |