File:Chicken HH20 MyoR expression 02.jpg: Difference between revisions

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MyoR and MyoD Expression domains during Chick first Branchial Arch Development

Lateral view of a HH20 chick embryo hybridized with a MyoR probe.

(A) Lateral view of a HH20 chick embryo hybridized with a MyoR probe. HH20 (B,C) embryo was frontally sectioned at the head level. The plane of section is indicated in the panel A. Adjacent sections from each stage were hybridized with DIG-labelled antisense probes for either MyoR (B) or MyoD (C).

MyoR delineates the myogenic core of the first branchial arch (B) and is subsequently expressed in all branchiomeric muscles.

MyoD transcripts are first detected in a lateral sub-region of the MyoR domain at HH20 (B,C, arrows).

BA1, first branchial arch,
di, diencephalon
e, eye

fl, forelimb
hl, hindlimb
mb, mandibular arch

mes, mesenchephalon
MR, medial rectus
mx, maxillary arch

ph, pharynx
tel, telencephalon
VO, ventral oblique
VR, ventral rectus.

MyoR - (Myogenic Repressor) basic helix-loop-helix (bHLH) factor expressed in undifferentiated myoblasts and downregulated during differentiation. OMIM603628

Links: Image - MyoR | Image - MyoR and MyoD | Head Development | Chicken Development | Molecular Development

Reference

<pubmed>19198652</pubmed>| PLoS One.

Copyright

© 2009 Grenier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Grenier J, Teillet M-A, Grifone R, Kelly RG, Duprez D (2009) Relationship between Neural Crest Cells and Cranial Mesoderm during Head Muscle Development. PLoS ONE 4(2): e4381. doi:10.1371/journal.pone.0004381

Figure 1. journal.pone.0004381.g001.jpg Original figure altered in size and labelling.

doi:10.1371/journal.pone.0004381.g001

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Copyright holder	Creative Commons Attribution License
Copyright status	Copyright status not set
Unique ID of original document	xmp.did:0980117407206811822A95B2C40AFEF5
Software used	Adobe Photoshop CS6 Macintosh
Short title	Figure 1
IIM version	2

@@ Line 1: / Line 1: @@
-== MyoR Expression domains during chick first branchial arch development==
+== MyoR and MyoD Expression domains during Chick first Branchial Arch Development==
 Lateral view of a HH20 chick embryo hybridized with a MyoR probe.
@@ Line 7: / Line 7: @@
 MyoD transcripts are first detected in a lateral sub-region of the MyoR domain at HH20 (B,C, arrows).
+{|
+|
+* BA1, first branchial arch,
+* di, diencephalon
+* e, eye
+|
+* fl, forelimb
+* hl, hindlimb
+* mb, mandibular arch
+|
+* mes, mesenchephalon
+* MR, medial rectus
+* mx, maxillary arch
+|
+* ph, pharynx
+* tel, telencephalon
+* VO, ventral oblique
+* VR, ventral rectus.
+|}
-'''MyoR''' - (Myogenic Repressor) basic helix-loop-helix (bHLH) factor expressed in undifferentiated myoblasts and downregulated during differentiation.  [http://omim.org/entry/603628 OMIM603628]
+* '''MyoR''' - (Myogenic Repressor) basic helix-loop-helix (bHLH) factor expressed in undifferentiated myoblasts and downregulated during differentiation.  [http://omim.org/entry/603628 OMIM603628]
+'''Links:''' [[:File:Chicken HH20 MyoR expression 01.jpg|Image - MyoR]] | [[:File:Chicken HH20 MyoR expression 02.jpg|Image - MyoR and MyoD]] | [[Head Development]] | [[Chicken Development]] | [[Molecular Development]]
 ===Reference===
@@ Line 21: / Line 42: @@
 Figure 1. journal.pone.0004381.g001.jpg Original figure altered in size and labelling.
-[[Category:Chicken]]
+[[Category:Chicken]][[Category:Head]]
 doi:10.1371/journal.pone.0004381.g001
-PLoS One. 2009;4(2):e4381. doi: 10.1371/journal.pone.0004381. Epub 2009 Feb 9.
-Relationship between neural crest cells and cranial mesoderm during head muscle development.
-Grenier J1, Teillet MA, Grifone R, Kelly RG, Duprez D.
-Author information
-Abstract
-BACKGROUND:
-In vertebrates, the skeletal elements of the jaw, together with the connective tissues and tendons, originate from neural crest cells, while the associated muscles derive mainly from cranial mesoderm. Previous studies have shown that neural crest cells migrate in close association with cranial mesoderm and then circumscribe but do not penetrate the core of muscle precursor cells of the branchial arches at early stages of development, thus defining a sharp boundary between neural crest cells and mesodermal muscle progenitor cells. Tendons constitute one of the neural crest derivatives likely to interact with muscle formation. However, head tendon formation has not been studied, nor have tendon and muscle interactions in the head.
-METHODOLOGY/PRINCIPAL FINDINGS:
-Reinvestigation of the relationship between cranial neural crest cells and muscle precursor cells during development of the first branchial arch, using quail/chick chimeras and molecular markers revealed several novel features concerning the interface between neural crest cells and mesoderm. We observed that neural crest cells migrate into the cephalic mesoderm containing myogenic precursor cells, leading to the presence of neural crest cells inside the mesodermal core of the first branchial arch. We have also established that all the forming tendons associated with branchiomeric and eye muscles are of neural crest origin and express the Scleraxis marker in chick and mouse embryos. Moreover, analysis of Scleraxis expression in the absence of branchiomeric muscles in Tbx1(-/-) mutant mice, showed that muscles are not necessary for the initiation of tendon formation but are required for further tendon development.
-CONCLUSIONS/SIGNIFICANCE:
-This results show that neural crest cells and muscle progenitor cells are more extensively mixed than previously believed during arch development. In addition, our results show that interactions between muscles and tendons during craniofacial development are similar to those observed in the limb, despite the distinct embryological origin of these cell types in the head.
-PMID 19198652