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Revision as of 07:12, 7 October 2014

Embryo Epigenetics

2014 Nobel Prize in Physiology or Medicine

John O´Keefe, May-Britt Moser and Edvard I. Moser - for their discoveries of cells that constitute a positioning system in the brain

(More? Hippocampus Development)

Older News Articles

Embryo Epigenetics - after fertilisation human embryos loose DNA methylation from most of the genome.
WHO - Trends in Maternal Mortality 1990 to 2013. Statistics - Maternal Mortality | WHO Report Page
WHO - polio has re-emerged as a public health emergency. Polio Virus
Trisomy 21 Genome-wide Effects
RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers press release April 1, 2014 | Science April 2014

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-[[File:Epigenetics_cartoon.jpg|250px|left]]
+[[File:Human hippocampus cartoon.jpg|250px|left]]
-| '''Embryos Reprogram their Epigenetics'''
+| '''2014 Nobel Prize in Physiology or Medicine'''
-Two recent studies show that after fertilisation human embryos loose DNA methylation from most of the genome. This implies that there is an early "reprogramming" or "resetting" of the embryo's epigenetic status.
+John O´Keefe, May-Britt Moser and Edvard I. Moser - ''for their discoveries of cells that constitute a positioning system in the brain''
-* '''The DNA methylation landscape of human early embryos''' PMID 25079557 "We show that the major wave of genome-wide demethylation is complete at the 2-cell stage, contrary to previous observations in mice. Moreover, the demethylation of the paternal genome is much faster than that of the maternal genome, and by the end of the zygotic stage the genome-wide methylation level in male pronuclei is already lower than that in female pronuclei."
+:(More? [[Neural_-_Hippocampus_Development|Hippocampus Development]])
-* '''DNA methylation dynamics of the human preimplantation embryo''' PMID 25079558 "our data confirm that paternal genome demethylation is a general attribute of early mammalian development that is characterized by distinct modes of epigenetic regulation."
-:(More? [[Molecular Development - Epigenetics|Epigenetics]] | Nature. 2014 Jul PMID 25079558 PMID 25079557)
 [[Template_talk:Main_Page_News|Older News Articles]]
+* Embryo Epigenetics - after fertilisation human embryos loose DNA methylation from most of the genome.
 * WHO - Trends in Maternal Mortality 1990 to 2013. [[Statistics - Maternal Mortality]] | [http://www.who.int/reproductivehealth/publications/monitoring/maternal-mortality-2013/en WHO Report Page]
 * WHO - polio has re-emerged as a public health emergency.  [[Abnormal Development - Polio Virus|Polio Virus]]