File:Notch signalling in muscle regeneration cartoon.jpg: Difference between revisions

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Notch signalling activity during muscle regeneration

Muscle quiescent, G0-arrested satellite cells have high Notch activity (purple line), which maintains Pax7 and inhibits Myod (indirectly: dotted line) and Myogenin (directly via Hey1) expression. Immediately after activation, satellite cells downregulate Notch activity and express Myod that is required for appropriate Cdc6 expression and S-phase entry. During the amplification phase high Notch activity is restricted to upstream, Pax7Hi cells that remain undifferentiated and self-renew to replenish the satellite cell pool. Notch activation is triggered by Dll1-bearing differentiating myoblasts. Non-muscle cells, like infiltrating inflammatory cells and fibro/adipogenic progenitors could also trigger or influence Notch activation. The expression of Dll ligands by the mature myofibres is likely, but remains to be demonstrated.

Links: Notch | Muscle Development

Reference

<pubmed>24472470</pubmed>| BMC Dev Biol.

Copyright

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

1471-213X-14-2-1-l.jpg

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current	13:56, 23 March 2014		1,000 × 588 (102 KB)	Z8600021 (talk \| contribs)	Notch signalling activity during muscle regeneration. Upper panel: In wild type muscle, quiescent, G0-arrested satellite cells have high Notch activity (purple line), which maintains Pax7 and inhibits Myod (indirectly: dotted line) and Myogenin (direct...

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Developmental Signals - Notch

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-Notch signalling activity during muscle regeneration. Upper panel: In wild type muscle, quiescent, G0-arrested satellite cells have high Notch activity (purple line), which maintains Pax7 and inhibits Myod (indirectly: dotted line) and Myogenin (directly via Hey1) expression. Immediately after activation, satellite cells downregulate Notch activity and express Myod that is required for appropriate Cdc6 expression and S-phase entry. During the amplification phase high Notch activity is restricted to upstream, Pax7Hi cells that remain undifferentiated and self-renew to replenish the satellite cell pool. Notch activation is triggered by Dll1-bearing differentiating myoblasts. Non-muscle cells, like infiltrating inflammatory cells and fibro/adipogenic progenitors could also trigger or influence Notch activation. The expression of Dll ligands by the mature myofibres is likely, but remains to be demonstrated. Lower panel: Rbpj null satellite cells (no Notch activity: dotted purple line) enter the cell cycle normally and start proliferating. Mutant satellite cells differentiate faster (yellow cells) and fail to self-renew.
+==Notch signalling activity during muscle regeneration==
+Muscle quiescent, G0-arrested satellite cells have high Notch activity (purple line), which maintains Pax7 and inhibits Myod (indirectly: dotted line) and Myogenin (directly via Hey1) expression. Immediately after activation, satellite cells downregulate Notch activity and express Myod that is required for appropriate Cdc6 expression and S-phase entry. During the amplification phase high Notch activity is restricted to upstream, Pax7Hi cells that remain undifferentiated and self-renew to replenish the satellite cell pool. Notch activation is triggered by Dll1-bearing differentiating myoblasts. Non-muscle cells, like infiltrating inflammatory cells and fibro/adipogenic progenitors could also trigger or influence Notch activation. The expression of Dll ligands by the mature myofibres is likely, but remains to be demonstrated.
+:'''Links:''' [[Developmental Signals - Notch|Notch]] | [[Musculoskeletal_System_-_Muscle_Development|Muscle Development]]
+===Reference===
+<pubmed>24472470</pubmed>| [http://www.biomedcentral.com/1471-213X/14/2 BMC Dev Biol.]
+====Copyright====
+© 2014 Mourikis and Tajbakhsh; licensee BioMed Central Ltd.
+This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
 -213X-14-2-1-l.jpg
+[[Category:Muscle]] [[Category:Molecular]] [[Category:Notch]][[Category:Cartoon]]