ACPS Seminar 2014 - Implantation: Difference between revisions
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* Most published human studies are based upon only a very few tissue samples. | |||
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[[File:HFTB_graph_4.jpg]] | [[File:HFTB_graph_4.jpg]] |
Revision as of 12:55, 18 March 2014
Understanding Implantation and the new Uterine Tube Biobank
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Human Development - Week 1
<mediaplayer width='500' height='450' image="http://embryology.med.unsw.edu.au/embryology/images/0/07/Human_blastocyst_day_1-5.jpg">File:Human_blastocyst_day_3-6.mp4</mediaplayer>
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Human Development - Week 2
<mediaplayer width='250' height='260' image="http://php.med.unsw.edu.au/embryology/images/a/a9/Week2_001_icon.jpg">File:Week2_001.mp4</mediaplayer> |
This animation shows the process of implantation, occurring during week 2 (GA week 4) of development in humans. The beginning of the animation shows adplantation to the the uterus lining (endometrium epithelium). The hatched blastocyst with a flat outer layer of trophoblast cells (green), the inner cell mass which has formed into the bilaminar embryo (epiblast and hypoblast) and the large fluid-filled space (blastocoel).
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Early Implantation
- Most data from animal models (mouse) of implantation.
- Very little human data for early (first trimester) events.
Adplantation Signaling [2] | Early Implantation Signaling |
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Ectopic Implantation
<mediaplayer width='660' height='540' image="http://php.med.unsw.edu.au/embryology/images/f/f0/Ectopic_01.jpg">File:Ectopic_01.mp4</mediaplayer> | Movie shows the most common form of ectopic pregnancies, those that occur with premature implantation in the uterine or fallopian tubes, a tubal pregnancy.
The movie shows an ectopic embryo (less than 10 weeks gestation) which has implanted in the left uterine tube.
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Ectopic GA Week 7 | Ectopic GA Week 10 |
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Image: Dr Steven O'Connor (Houston, Texas) - Other embryo images. |
First trimester placental villi | Term placental villi |
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Uterine Implantation
Tube Biobank
- Most published human studies are based upon only a very few tissue samples.
Tube Analysis Techniques
Protein Expression
mRNA Expression
Immune Protection
HLA-G - Human leukocyte antigen G (HLA-G, HLA-6.0; HLA60, T-CELL A LOCUS; TCA)
- Expression by fetal cells protects from immune rejection.
- HLA-G is a non-classical HLA class-Ib molecule expressed by the extravillous cytotrophoblasts (EVT) of the placenta.
- 338 AA protein, mRNA differential splicing gives rise to 7 isoforms: 4 membrane-bound forms (HLA-G1, G2, G3, G4) and 3 soluble forms (sHLA-G5, G6, G7)
HLA-G expression (red) on trophoblast cell columns (CC) and extravillous trophoblasts.[3] |
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
References
Cite this page: Hill, M.A. (2024, June 10) Embryology ACPS Seminar 2014 - Implantation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/ACPS_Seminar_2014_-_Implantation
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G