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Steroid hormone receptor signaling

Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors.

Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus.

There, the receptor dimerizes, binds specific sequences in the DNA, called Hormone Responsive Elements or HREs, and recruits a number of coregulators that facilitate gene transcription.

This latter step can be modulated by receptor antagonists like tamoxifen (T), and cellular signalling pathways.

Legend

hormone binding
chaperone interaction
nuclear translocation
receptor dimerization
DNA binding
putative membrane-bound receptors
coregulator recruitment
transcription
proteasomal degradation
modulation by cellular signalling pathways
antagonist resistance

Links: Endocrine System Development

Reference

<pubmed>17464358</pubmed>| PMC1853070 | Nucl Recept Signal.

Copyright

© 2007, Griekspoor et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.

Original file name: Figure 2 Big_nrs05003.f2.gif http://www.nursa.org/ejournal/published/05003/big_nrs05003.f2.gif

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Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan

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current	18:11, 5 October 2010		800 × 835 (105 KB)	S8600021 (talk \| contribs)	==Steroid hormone receptor signaling== Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock

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@@ Line 1: / Line 1: @@
 ==Steroid hormone receptor signaling==
-Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus. There, the receptor dimerizes, binds specific sequences in the DNA, called Hormone Responsive Elements or HREs, and recruits a number of coregulators that facilitate gene transcription. This latter step can be modulated by receptor antagonists like tamoxifen (T), and cellular signalling pathways.
+{|
+| width="400px" valign="top"|Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors.
+Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus.
-'''Legend'''
+There, the receptor dimerizes, binds specific sequences in the DNA, called Hormone Responsive Elements or HREs, and recruits a number of coregulators that facilitate gene transcription.
+This latter step can be modulated by receptor antagonists like tamoxifen (T), and cellular signalling pathways.
+| '''Legend'''
 # hormone binding
@@ Line 16: / Line 21: @@
 # modulation by cellular signalling pathways
 # antagonist resistance
+|}
+:'''Links:''' [[Endocrine System Development]]
-Original file name: Figure 2 Big_nrs05003.f2.gif http://www.nursa.org/ejournal/published/05003/big_nrs05003.f2.gif
 ===Reference===
@@ Line 25: / Line 31: @@
-Copyright © 2007, Griekspoor et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
+====Copyright====
+© 2007, Griekspoor et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
+Original file name: Figure 2 Big_nrs05003.f2.gif http://www.nursa.org/ejournal/published/05003/big_nrs05003.f2.gif
 [[Category:Molecular]] [[Category:Endocrine]] [[Category:Cartoon]]