Talk:Neural - Mesencephalon Development

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Cite this page: Hill, M.A. (2019, September 20) Embryology Neural - Mesencephalon Development. Retrieved from


Cytoarchitectural and functional abnormalities of the inferior colliculus in sudden unexplained perinatal death

Medicine (Baltimore). 2015 Feb;94(6):e487. doi: 10.1097/MD.0000000000000487.

Lavezzi AM1, Pusiol T, Matturri L.


The inferior colliculus is a mesencephalic structure endowed with serotonergic fibers that plays an important role in the processing of acoustic information. The implication of the neuromodulator serotonin also in the aetiology of sudden unexplained fetal and infant death syndromes and the demonstration in these pathologies of developmental alterations of the superior olivary complex (SOC), a group of pontine nuclei likewise involved in hearing, prompted us to investigate whether the inferior colliculus may somehow contribute to the pathogenetic mechanism of unexplained perinatal death. Therefore, we performed in a wide set of fetuses and infants, aged from 33 gestational weeks to 7 postnatal months and died of both known and unknown cause, an in-depth anatomopathological analysis of the brainstem, particularly of the midbrain. Peculiar neuroanatomical and functional abnormalities of the inferior colliculus, such as hypoplasia/structural disarrangement and immunonegativity or poor positivity of serotonin, were exclusively found in sudden death victims, and not in controls. In addition, these alterations were frequently related to dysgenesis of connected structures, precisely the raphé nuclei and the superior olivary complex, and to nicotine absorption in pregnancy. We propose, on the basis of these results, the involvement of the inferior colliculus in more important functions than those related to hearing, as breathing and, more extensively, all the vital activities, and then in pathological conditions underlying a sudden death in vulnerable periods of the autonomic nervous system development, particularly associated to harmful risk factors as cigarette smoking.

PMID 25674737


Misexpression of Gbx2 throughout the mesencephalon by a conditional gain-of-function transgene leads to deletion of the midbrain and cerebellum in mice

Sunmonu NA, Chen L, Li JY. Genesis. 2009 Oct;47(10):667-73. PMID: 19603509

Characterizing the mesencephalon using susceptibility-weighted imaging

Manova ES, Habib CA, Boikov AS, Ayaz M, Khan A, Kirsch WM, Kido DK, Haacke EM. AJNR Am J Neuroradiol. 2009 Mar;30(3):569-74. Epub 2008 Dec 26. PMID: 19112064


Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

Omodei D, Acampora D, Mancuso P, Prakash N, Di Giovannantonio LG, Wurst W, Simeone A. Development. 2008 Oct;135(20):3459-70. PMID: 18820178


Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon

Shim S, Kim Y, Shin J, Kim J, Park S. Mol Cell Biol. 2007 Mar;27(5):1614-30. Epub 2006 Dec 18. PMID: 17178831

Isthmus organizer and regionalization of the mesencephalon and metencephalon

Nakamura H, Watanabe Y. Int J Dev Biol. 2005;49(2-3):231-5. Review. PMID: 15906236

Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon

Scholpp S, Lohs C, Brand M. Development. 2003 Oct;130(20):4881-93. Epub 2003 Aug 13. Erratum in: Development. 2003 Nov;130(21):5293. PMID: 12917294

Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development

Matsunaga E, Katahira T, Nakamura H. Development. 2002 Nov;129(22):5269-77. PMID: 12399317