|About Discussion Pages|
Cite this page: Hill, M.A. (2019, June 17) Embryology Mesoderm. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Mesoderm
10 Most Recent Papers
Note - This sub-heading shows an automated computer PubMed search using the listed sub-heading term. References appear in this list based upon the date of the actual page viewing. Therefore the list of references do not reflect any editorial selection of material based on content or relevance. In comparison, references listed on the content page and discussion page (under the publication year sub-headings) do include editorial selection based upon relevance and availability. (More? Pubmed Most Recent)
<pubmed limit=5>Mesoderm Development</pubmed>
Analysis of extraembryonic mesodermal structure formation in the absence of morphological primitive streak
Dev Growth Differ. 2016 Aug;58(6):522-9. doi: 10.1111/dgd.12294. Epub 2016 Jun 8.
Jin JZ1, Zhu Y1, Warner D1, Ding J1.
During mouse gastrulation, the primitive streak is formed on the posterior side of the embryo. Cells migrate out of the primitive streak to form the future mesoderm and endoderm. Fate mapping studies revealed a group of cell migrate through the proximal end of the primitive streak and give rise to the extraembryonic mesoderm tissues such as the yolk sac blood islands and allantois. However, it is not clear whether the formation of a morphological primitive streak is required for the development of these extraembryonic mesodermal tissues. Loss of the Cripto gene in mice dramatically reduces, but does not completely abolish, Nodal activity leading to the absence of a morphological primitive streak. However, embryonic erythrocytes are still formed and assembled into the blood islands. In addition, Cripto mutant embryos form allantoic buds. However, Drap1 mutant embryos have excessive Nodal activity in the epiblast cells before gastrulation and form an expanded primitive streak, but no yolk sac blood islands or allantoic bud formation. Lefty2 embryos also have elevated levels of Nodal activity in the primitive streak during gastrulation, and undergo normal blood island and allantois formation. We therefore speculate that low level of Nodal activity disrupts the formation of morphological primitive streak on the posterior side, but still allows the formation of primitive streak cells on the proximal side, which give rise to the extraembryonic mesodermal tissues formation. Excessive Nodal activity in the epiblast at pre-gastrulation stage, but not in the primitive streak cells during gastrulation, disrupts extraembryonic mesoderm development. KEYWORDS: Cripto; Drap1; Lefty2; allantois; blood island; primitive streak PMID: 27273137 DOI: 10.1111/dgd.12294
BRACHYURY directs histone acetylation to target loci during mesoderm development
EMBO Rep. 2018 Jan;19(1):118-134. doi: 10.15252/embr.201744201. Epub 2017 Nov 15.
Beisaw A1,2,3, Tsaytler P1, Koch F1, Schmitz SU1, Melissari MT1, Senft AD1, Wittler L1, Pennimpede T1, Macura K1, Herrmann BG1,4, Grote P5,6.
T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A single point mutation (TY88A) results in decreased histone 3 lysine 27 acetylation (H3K27ac) at T target sites, including the T locus, suggesting that T autoregulates the maintenance of its expression and functions by recruiting permissive chromatin modifications to putative enhancers during mesoderm specification. Our data indicate that T mediates H3K27ac recruitment through a physical interaction with p300. In addition, we determine that T plays a prominent role in the specification of hematopoietic and endothelial cell types. Hematopoietic and endothelial gene expression programs are disrupted in TY88A mutant embryos, leading to a defect in the differentiation of hematopoietic progenitors. We show that this role of T is mediated, at least in part, through activation of a distal Lmo2 enhancer. KEYWORDS: Brachyury ; Lmo2 ; H3K27 acetylation; T‐box factors; autoregulation PMID: 29141987 PMCID: PMC5757217 [Available on 2019-01-01] DOI: 10.15252/embr.201744201
STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10928-E10936. doi: 10.1073/pnas.1713535114. Epub 2017 Dec 4.
Bazzi H1,2,3, Soroka E2,3, Alcorn HL4, Anderson KV1.
Regulated mesoderm migration is necessary for the proper morphogenesis and organ formation during embryonic development. Cell migration and its dependence on the cytoskeleton and signaling machines have been studied extensively in cultured cells; in contrast, remarkably little is known about the mechanisms that regulate mesoderm cell migration in vivo. Here, we report the identification and characterization of a mouse mutation in striatin-interacting protein 1 (Strip1) that disrupts migration of the mesoderm after the gastrulation epithelial-to-mesenchymal transition (EMT). STRIP1 is a core component of the biochemically defined mammalian striatin-interacting phosphatases and kinase (STRIPAK) complexes that appear to act through regulation of protein phosphatase 2A (PP2A), but their functions in mammals in vivo have not been examined. Strip1-null mutants arrest development at midgestation with profound disruptions in the organization of the mesoderm and its derivatives, including a complete failure of the anterior extension of axial mesoderm. Analysis of cultured mesoderm explants and mouse embryonic fibroblasts from null mutants shows that the mesoderm migration defect is correlated with decreased cell spreading, abnormal focal adhesions, changes in the organization of the actin cytoskeleton, and decreased velocity of cell migration. The results show that STRIPAK complexes are essential for cell migration and tissue morphogenesis in vivo. KEYWORDS: PP2A; STRIP1; STRIPAK; cell migration; mouse embryo PMID: 29203676 PMCID: PMC5754794 DOI: 10.1073/pnas.1713535114
A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells
PLoS One. 2017 Jun 27;12(6):e0179613. doi: 10.1371/journal.pone.0179613. eCollection 2017.
Ulfenborg B1, Karlsson A2, Riveiro M2, Améen C3, Åkesson K3, Andersson CX3, Sartipy P1,4, Synnergren J1.
The development of high-throughput biomolecular technologies has resulted in generation of vast omics data at an unprecedented rate. This is transforming biomedical research into a big data discipline, where the main challenges relate to the analysis and interpretation of data into new biological knowledge. The aim of this study was to develop a framework for biomedical big data analytics, and apply it for analyzing transcriptomics time series data from early differentiation of human pluripotent stem cells towards the mesoderm and cardiac lineages. To this end, transcriptome profiling by microarray was performed on differentiating human pluripotent stem cells sampled at eleven consecutive days. The gene expression data was analyzed using the five-stage analysis framework proposed in this study, including data preparation, exploratory data analysis, confirmatory analysis, biological knowledge discovery, and visualization of the results. Clustering analysis revealed several distinct expression profiles during differentiation. Genes with an early transient response were strongly related to embryonic- and mesendoderm development, for example CER1 and NODAL. Pluripotency genes, such as NANOG and SOX2, exhibited substantial downregulation shortly after onset of differentiation. Rapid induction of genes related to metal ion response, cardiac tissue development, and muscle contraction were observed around day five and six. Several transcription factors were identified as potential regulators of these processes, e.g. POU1F1, TCF4 and TBP for muscle contraction genes. Pathway analysis revealed temporal activity of several signaling pathways, for example the inhibition of WNT signaling on day 2 and its reactivation on day 4. This study provides a comprehensive characterization of biological events and key regulators of the early differentiation of human pluripotent stem cells towards the mesoderm and cardiac lineages. The proposed analysis framework can be used to structure data analysis in future research, both in stem cell differentiation, and more generally, in biomedical big data analytics.
PMID: 28654683 PMCID: PMC5487013 DOI: 10.1371/journal.pone.0179613
An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development
Sci Data. 2016 Dec 20;3:160109. doi: 10.1038/sdata.2016.109.
Koh PW1, Sinha R2, Barkal AA2, Morganti RM2, Chen A2, Weissman IL2, Ang LT3, Kundaje A1, Loh KM2.
Mesoderm is the developmental precursor to myriad human tissues including bone, heart, and skeletal muscle. Unravelling the molecular events through which these lineages become diversified from one another is integral to developmental biology and understanding changes in cellular fate. To this end, we developed an in vitro system to differentiate human pluripotent stem cells through primitive streak intermediates into paraxial mesoderm and its derivatives (somites, sclerotome, dermomyotome) and separately, into lateral mesoderm and its derivatives (cardiac mesoderm). Whole-population and single-cell analyses of these purified populations of human mesoderm lineages through RNA-seq, ATAC-seq, and high-throughput surface marker screens illustrated how transcriptional changes co-occur with changes in open chromatin and surface marker landscapes throughout human mesoderm development. This molecular atlas will facilitate study of human mesoderm development (which cannot be interrogated in vivo due to restrictions on human embryo studies) and provides a broad resource for the study of gene regulation in development at the single-cell level, knowledge that might one day be exploited for regenerative medicine. PMID: 27996962 PMCID: PMC5170597 DOI: 10.1038/sdata.2016.109
Genesis. 2014 Jun;52(6):503-14. doi: 10.1002/dvg.22783. Epub 2014 May 5.
Follow your gut: relaying information from the site of left-right symmetry breaking in the mouse
Saijoh Y1, Viotti M, Hadjantonakis AK.
A central unresolved question in the molecular cascade that drives establishment of left-right (LR) asymmetry in vertebrates are the mechanisms deployed to relay information between the midline site of symmetry-breaking and the tissues which will execute a program of asymmetric morphogenesis. The cells located between these two distant locations must provide the medium for signal relay. Of these, the gut endoderm is an attractive candidate tissue for signal transmission since it comprises the epithelium that lies between the node, where asymmetry originates, and the lateral plate, where asymmetry can first be detected. Here, focusing on the mouse as a model, we review our current understanding and entertain open questions concerning the relay of LR information from its origin. © 2014 Wiley Periodicals, Inc. KEYWORDS: Connexin; LR asymmetry; Nodal, Sox17; extracellular matrix; gap junction intercellular communication; gastrulation; gut endoderm; lateral plate mesoderm; midline; mouse embryo; node
Salient features of the ciliated organ of asymmetry
Bioarchitecture. 2014 Jan-Feb;4(1):6-15. doi: 10.4161/bioa.28014. Epub 2014 Jan 31.
Many internal organs develop distinct left and right sides that are essential for their functions. In several vertebrate embryos, motile cilia generate an asymmetric fluid flow that plays an important role in establishing left-right (LR) signaling cascades. These 'LR cilia' are found in the ventral node and posterior notochordal plate in mammals, the gastrocoel roof plate in amphibians and Kupffer's vesicle in teleost fish. I consider these transient ciliated structures as the 'organ of asymmetry' that directs LR patterning of the developing embryo. Variations in size and morphology of the organ of asymmetry in different vertebrate species have raised questions regarding the fundamental features that are required for LR determination. Here, I review current models for how LR asymmetry is established in vertebrates, discuss the cellular architecture of the ciliated organ of asymmetry and then propose key features of this organ that are critical for orienting the LR body axis. KEYWORDS: Kupffer’s vesicle; Left-right asymmetry; calcium ion flux; cilia; congenital heart defects; gastrocoel roof plate; posterior notochordal plate
Mechanisms of left-right asymmetry and patterning: driver, mediator and responder
F1000Prime Rep. 2014 Dec 1;6:110. doi: 10.12703/P6-110. eCollection 2014.
Hamada H1, Tam PP2.
The establishment of a left-right (LR) organizer in the form of the ventral node is an absolute prerequisite for patterning the tissues on contralateral sides of the body of the mouse embryo. The experimental findings to date are consistent with a mechanistic paradigm that the laterality information, which is generated in the ventral node, elicits asymmetric molecular activity and cellular behaviour in the perinodal tissues. This information is then relayed to the cells in the lateral plate mesoderm (LPM) when the left-specific signal is processed and translated into LR body asymmetry. Here, we reflect on our current knowledge and speculate on the following: (a) what are the requisite anatomical and functional attributes of an LR organizer, (b) what asymmetric information is emanated from this organizer, and (c) how this information is transferred across the paraxial tissue compartment and elicits a molecular response specifically in the LPM.
PMID 25580264 [PubMed] PMCID: PMC4275019
Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning
A role for Vg1/Nodal signaling in specification of the intermediate mesoderm
Development. 2013 Apr;140(8):1819-29. doi: 10.1242/dev.093740.
Fleming BM, Yelin R, James RG, Schultheiss TM. Source Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
The intermediate mesoderm (IM) is the embryonic source of all kidney tissue in vertebrates. The factors that regulate the formation of the IM are not yet well understood. Through investigations in the chick embryo, the current study identifies and characterizes Vg1/Nodal signaling (henceforth referred to as 'Nodal-like signaling') as a novel regulator of IM formation. Excess Nodal-like signaling at gastrulation stages resulted in expansion of the IM at the expense of the adjacent paraxial mesoderm, whereas inhibition of Nodal-like signaling caused repression of IM gene expression. IM formation was sensitive to levels of the Nodal-like pathway co-receptor Cripto and was inhibited by a truncated form of the secreted molecule cerberus, which specifically blocks Nodal, indicating that the observed effects are specific to the Nodal-like branch of the TGFβ signaling pathway. The IM-promoting effects of Nodal-like signaling were distinct from the known effects of this pathway on mesoderm formation and left-right patterning, a finding that can be attributed to specific time windows for the activities of these Nodal-like functions. Finally, a link was observed between Nodal-like and BMP signaling in the induction of IM. Activation of IM genes by Nodal-like signaling required an active BMP signaling pathway, and Nodal-like signals induced phosphorylation of Smad1/5/8, which is normally associated with activation of BMP signaling pathways. We postulate that Nodal-like signaling regulates IM formation by modulating the IM-inducing effects of BMP signaling.
EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment
PLoS Biol. 2011 Mar;9(3):e1000597. Epub 2011 Mar 1.
Rohani N, Canty L, Luu O, Fagotto F, Winklbauer R. Source Department of Biology, McGill University, Montreal, Quebec, Canada.
Abstract BACKGROUND: The primordial organization of the metazoan body is achieved during gastrulation by the establishment of the germ layers. Adhesion differences between ectoderm, mesoderm, and endoderm cells could in principle be sufficient to maintain germ layer integrity and prevent intermixing. However, in organisms as diverse as fly, fish, or amphibian, the ectoderm-mesoderm boundary not only keeps these germ layers separated, but the ectoderm also serves as substratum for mesoderm migration, and the boundary must be compatible with repeated cell attachment and detachment.
PRINCIPAL FINDINGS: We show that localized detachment resulting from contact-induced signals at the boundary is at the core of ectoderm-mesoderm segregation. Cells alternate between adhesion and detachment, and detachment requires ephrinB/EphB signaling. Multiple ephrinB ligands and EphB receptors are expressed on each side of the boundary, and tissue separation depends on forward signaling across the boundary in both directions, involving partially redundant ligands and receptors and activation of Rac and RhoA.
CONCLUSION: This mechanism differs from a simple differential adhesion process of germ layer formation. Instead, it involves localized responses to signals exchanged at the tissue boundary and an attachment/detachment cycle which allows for cell migration across a cellular substratum.
PMID 21390298 [PubMed - in process] PMCID: PMC3046958
Brachyury establishes the embryonic mesodermal progenitor niche
Genes Dev. 2010 Dec 15;24(24):2778-83.
Martin BL, Kimelman D.
SourceDepartment of Biochemistry, University of Washington, Seattle, Washington 98195, USA. AbstractFormation of the early vertebrate embryo depends on a Brachyury/Wnt autoregulatory loop within the posterior mesodermal progenitors. We show that exogenous retinoic acid (RA), which dramatically truncates the embryo, represses expression of the zebrafish brachyury ortholog no tail (ntl), causing a failure to sustain the loop. We found that Ntl functions normally to protect the autoregulatory loop from endogenous RA by directly activating cyp26a1 expression. Thus, the embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells.
Mesoderm Development - Limit Title
1: Aulehla A, Pourquié O. Signaling gradients during paraxial mesoderm development. Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a000869. PubMed PMID: 20182616; PubMed Central PMCID: PMC2828275.
2: Callery EM, Thomsen GH, Smith JC. A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus. Dev Biol. 2010 Apr 1;340(1):75-87. Epub 2010 Jan 18. PubMed PMID: 20083100; PubMed Central PMCID: PMC2877776.
3: Duboc V, Lapraz F, Saudemont A, Bessodes N, Mekpoh F, Haillot E, Quirin M, Lepage T. Nodal and BMP2/4 pattern the mesoderm and endoderm during development of the sea urchin embryo. Development. 2010 Jan;137(2):223-35. PubMed PMID: 20040489.
4: Broitman-Maduro G, Owraghi M, Hung WW, Kuntz S, Sternberg PW, Maduro MF. The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development. Development. 2009 Aug;136(16):2735-46. Epub 2009 Jul 15. PubMed PMID: 19605496; PubMed Central PMCID: PMC2730403.
5: Bourdelas A, Li HY, Carron C, Shi DL. Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. Int J Dev Biol. 2009;53(7):1075-9. PubMed PMID: 19598125.
6: Klingseisen A, Clark IB, Gryzik T, M√ºller HA. Differential and overlapping functions of two closely related Drosophila FGF8-like growth factors in mesoderm development. Development. 2009 Jul;136(14):2393-402. Epub 2009 Jun 10. PubMed PMID: 19515694; PubMed Central PMCID: PMC2729350.
7: Grenier J, Teillet MA, Grifone R, Kelly RG, Duprez D. Relationship between neural crest cells and cranial mesoderm during head muscle development. PLoS One. 2009;4(2):e4381. Epub 2009 Feb 9. PubMed PMID: 19198652; PubMed Central PMCID: PMC2634972.
8: Schuster-Gossler K, Harris B, Johnson KR, Serth J, Gossler A. Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. BMC Dev Biol. 2009 Jan 22;9:6. PubMed PMID: 19161597; PubMed Central PMCID: PMC2637848.
9: Farin HF, Mansouri A, Petry M, Kispert A. T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm. J Biol Chem. 2008 Sep 12;283(37):25372-80. Epub 2008 Jul 21. PubMed PMID: 18644785.
10: Mugford JW, Sipil√§ P, Kobayashi A, Behringer RR, McMahon AP. Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol. 2008 Jul 15;319(2):396-405. Epub 2008 Apr 11. PubMed PMID: 18485340; PubMed Central PMCID: PMC2580739.
11: Reichenbach B, Delalande JM, Kolmogorova E, Prier A, Nguyen T, Smith CM, Holzschuh J, Shepherd IT. Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Dev Biol. 2008 Jun 1;318(1):52-64. Epub 2008 Mar 20. PubMed PMID: 18436202; PubMed Central PMCID: PMC2435286.
12: Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans SM, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb;135(4):647-57. Epub 2008 Jan 9. PubMed PMID: 18184728.
13: Dunty WC Jr, Biris KK, Chalamalasetty RB, Taketo MM, Lewandoski M, Yamaguchi TP. Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development. 2008 Jan;135(1):85-94. Epub 2007 Nov 28. PubMed PMID: 18045842.
14: Manfroid I, Delporte F, Baudhuin A, Motte P, Neumann CJ, Voz ML, Martial JA, Peers B. Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development. Development. 2007 Nov;134(22):4011-21. Epub 2007 Oct 17. PubMed PMID: 17942484.
15: Yukita A, Michiue T, Danno H, Asashima M. XSUMO-1 is required for normal mesoderm induction and axis elongation during early Xenopus development. Dev Dyn. 2007 Oct;236(10):2757-66. PubMed PMID: 17823940.
16: Burke AC. Development and evolution of the vertebrate mesoderm. Dev Dyn. 2007 Sep;236(9):2369-70. PubMed PMID: 17705304.
17: Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell. 2007 Oct;18(10):3764-75. Epub 2007 Jul 18. PubMed PMID: 17634284; PubMed Central PMCID: PMC1995707.
18: Sandmann T, Girardot C, Brehme M, Tongprasit W, Stolc V, Furlong EE. A core transcriptional network for early mesoderm development in Drosophila melanogaster. Genes Dev. 2007 Feb 15;21(4):436-49. PubMed PMID: 17322403; PubMed Central PMCID: PMC1804332.
19: Dong F, Sun X, Liu W, Ai D, Klysik E, Lu MF, Hadley J, Antoni L, Chen L, Baldini A, Francis-West P, Martin JF. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development. 2006 Dec;133(24):4891-9. Epub 2006 Nov 15. PubMed PMID: 17107996.
20: Mitchell T, Jones EA, Weeks DL, Sheets MD. Chordin affects pronephros development in Xenopus embryos by anteriorizing presomitic mesoderm. Dev Dyn. 2007 Jan;236(1):251-61. PubMed PMID: 17106888; PubMed Central PMCID: PMC2094051.
21: Steiner AB, Engleka MJ, Lu Q, Piwarzyk EC, Yaklichkin S, Lefebvre JL, Walters JW, Pineda-Salgado L, Labosky PA, Kessler DS. FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Development. 2006 Dec;133(24):4827-38. Epub 2006 Nov 8. PubMed PMID: 17092955; PubMed Central PMCID: PMC1676154.
22: Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006 Oct;133(19):3787-96. Epub 2006 Aug 30. PubMed PMID: 16943279.
23: Miura S, Davis S, Klingensmith J, Mishina Y. BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 2006 Oct;133(19):3767-75. Epub 2006 Aug 30. PubMed PMID: 16943278.
24: Gupta S, Zhu H, Zon LI, Evans T. BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development. 2006 Jun;133(11):2177-87. Epub 2006 May 3. PubMed PMID: 16672337.
25: Willey S, Ayuso-Sacido A, Zhang H, Fraser ST, Sahr KE, Adlam MJ, Kyba M, Daley GQ, Keller G, Baron MH. Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor. Blood. 2006 Apr 15;107(8):3122-30. Epub 2006 Jan 10. PubMed PMID: 16403910; PubMed Central PMCID: PMC1784910.
26: Liu F, van den Broek O, Destr√©e O, Hoppler S. Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development. Development. 2005 Dec;132(24):5375-85. Epub 2005 Nov 16. PubMed PMID: 16291789.
27: Murakami T, Hijikata T, Matsukawa M, Ishikawa H, Yorifuji H. Zebrafish protocadherin 10 is involved in paraxial mesoderm development and somitogenesis. Dev Dyn. 2006 Feb;235(2):506-14. PubMed PMID: 16261626.
28: Kouskoff V, Lacaud G, Schwantz S, Fehling HJ, Keller G. Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13170-5. Epub 2005 Sep 2. PubMed PMID: 16141334; PubMed Central PMCID: PMC1201570.
29: Perantoni AO, Timofeeva O, Naillat F, Richman C, Pajni-Underwood S, Wilson C, Vainio S, Dove LF, Lewandoski M. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development. 2005 Sep;132(17):3859-71. Epub 2005 Jul 27. PubMed PMID: 16049111.
30: Veltman IM, Vreede LA, Cheng J, Looijenga LH, Janssen B, Schoenmakers EF, Yeh ET, van Kessel AG. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Hum Mol Genet. 2005 Jul 15;14(14):1955-63. Epub 2005 May 25. PubMed PMID: 15917269.
31: Valente T, Junyent F, Auladell C. Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development. Dev Dyn. 2005 Jun;233(2):667-79. PubMed PMID: 15844099.
32: Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005 May;132(10):2489-99. Epub 2005 Apr 20. PubMed PMID: 15843411.
33: Pyati UJ, Webb AE, Kimelman D. Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development. Development. 2005 May;132(10):2333-43. Epub 2005 Apr 13. PubMed PMID: 15829520.
34: Molotkov A, Molotkova N, Duester G. Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn. 2005 Apr;232(4):950-7. PubMed PMID: 15739227.
35: Birsoy B, Berg L, Williams PH, Smith JC, Wylie CC, Christian JL, Heasman J. XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development. Development. 2005 Feb;132(3):591-602. Epub 2005 Jan 5. PubMed PMID: 15634697.
36: Ram√≠rez-Bergeron DL, Runge A, Dahl KD, Fehling HJ, Keller G, Simon MC. Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development. 2004 Sep;131(18):4623-34. PubMed PMID: 15342485.
37: Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T. The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97. PubMed PMID: 12808099; PubMed Central PMCID: PMC164855.
38: Hosono C, Takaira K, Matsuda R, Saigo K. Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development. Development. 2003 Feb;130(3):439-49. PubMed PMID: 12490551.
39: Dunwoodie SL, Beddington RS. The expression of the imprinted gene Ipl is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development. Int J Dev Biol. 2002;46(4):459-66. PubMed PMID: 12141432.
40: Amacher SL, Draper BW, Summers BR, Kimmel CB. The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate. Development. 2002 Jul;129(14):3311-23. PubMed PMID: 12091302.
41: Khot S, Ghaskadbi S. FGF signaling is essential for the early events in the development of the chick nervous system and mesoderm. Int J Dev Biol. 2001 Dec;45(8):877-85. PubMed PMID: 11804031.
42: Fujiwara T, Dunn NR, Hogan BL. Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13739-44. Epub 2001 Nov 13. PubMed PMID: 11707591; PubMed Central PMCID: PMC61111.
43: Zaffran S, K√ºchler A, Lee HH, Frasch M. biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila. Genes Dev. 2001 Nov 1;15(21):2900-15. PubMed PMID: 11691840; PubMed Central PMCID: PMC312807.
44: Castanon I, Von Stetina S, Kass J, Baylies MK. Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development. Development. 2001 Aug;128(16):3145-59. PubMed PMID: 11688563.
45: Furlong EE, Andersen EC, Null B, White KP, Scott MP. Patterns of gene expression during Drosophila mesoderm development. Science. 2001 Aug 31;293(5535):1629-33. Epub 2001 Aug 2. PubMed PMID: 11486054.
46: San Martin B, Bate M. Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila. Development. 2001 Jan;128(2):233-42. PubMed PMID: 11124118.
47: Taira Y, Kubo T, Natori S. Participation of transcription elongation factor XSII-K1 in mesoderm-derived tissue development in Xenopus laevis. J Biol Chem. 2000 Oct 13;275(41):32011-5. PubMed PMID: 10900206.
48: Kitajima S, Takagi A, Inoue T, Saga Y. MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000 Aug;127(15):3215-26. PubMed PMID: 10887078.
49: Vesque C, Ellis S, Lee A, Szabo M, Thomas P, Beddington R, Placzek M. Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling. Development. 2000 Jul;127(13):2795-809. PubMed PMID: 10851126.
50: Cheng AM, Thisse B, Thisse C, Wright CV. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Development. 2000 Mar;127(5):1049-61. PubMed PMID: 10662644.
51: Borello U, Coletta M, Tajbakhsh S, Leyns L, De Robertis EM, Buckingham M, Cossu G. Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development. 1999 Oct;126(19):4247-55. PubMed PMID: 10477293.
52: Mukai M, Kashikawa M, Kobayashi S. Induction of indora expression in pole cells by the mesoderm is required for female germ-line development in Drosophila melanogaster. Development. 1999 Feb;126(5):1023-9. PubMed PMID: 9927602.
53: Gering M, Rodaway AR, G√∂ttgens B, Patient RK, Green AR. The SCL gene specifies haemangioblast development from early mesoderm. EMBO J. 1998 Jul 15;17(14):4029-45. PubMed PMID: 9670018; PubMed Central PMCID: PMC1170736.
54: Amacher SL, Kimmel CB. Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm. Development. 1998 Apr;125(8):1397-406. PubMed PMID: 9502721.
55: Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, Buchwald M. The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development. 1998 May;125(10):1877-87. PubMed PMID: 9550720.
56: Harfe BD, Branda CS, Krause M, Stern MJ, Fire A. MyoD and the specification of muscle and non-muscle fates during postembryonic development of the C. elegans mesoderm. Development. 1998 Jul;125(13):2479-88. PubMed PMID: 9609831.
57: Broihier HT, Moore LA, Van Doren M, Newman S, Lehmann R. zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila. Development. 1998 Feb;125(4):655-66. PubMed PMID: 9435286.
58: Kim J, Lin JJ, Xu RH, Kung HF. Mesoderm induction by heterodimeric AP-1 (c-Jun and c-Fos) and its involvement in mesoderm formation through the embryonic fibroblast growth factor/Xbra autocatalytic loop during the early development of Xenopus embryos. J Biol Chem. 1998 Jan 16;273(3):1542-50. PubMed PMID: 9430694.
59: Armes NA, Smith JC. The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. Development. 1997 Oct;124(19):3797-804. PubMed PMID: 9367435.
60: Yin Z, Xu XL, Frasch M. Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development. 1997 Dec;124(24):4971-82. PubMed PMID: 9362473.
61: Ros MA, Sefton M, Nieto MA. Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development. Development. 1997 May;124(9):1821-9. PubMed PMID: 9165129.
62: Farmer SC, Sun CW, Winnier GE, Hogan BL, Townes TM. The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev. 1997 Mar 15;11(6):786-98. PubMed PMID: 9087432.
63: Boyle M, Bonini N, DiNardo S. Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm. Development. 1997 Mar;124(5):971-82. PubMed PMID: 9056773.
64: Kaestner KH, Bleckmann SC, Monaghan AP, Schl√∂ndorff J, Mincheva A, Lichter P, Sch√ºtz G. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development. 1996 Jun;122(6):1751-8. PubMed PMID: 8674414.
65: Dong Z, Xu RH, Kim J, Zhan SN, Ma WY, Colburn NH, Kung H. AP-1/jun is required for early Xenopus development and mediates mesoderm induction by fibroblast growth factor but not by activin. J Biol Chem. 1996 Apr 26;271(17):9942-6. PubMed PMID: 8626631.
66: Karavanov AA, Saint-Jeannet JP, Karavanova I, Taira M, Dawid IB. The LIM homeodomain protein Lim-1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development. Int J Dev Biol. 1996 Apr;40(2):453-61. PubMed PMID: 8793615.
67: Blanar MA, Crossley PH, Peters KG, Steingr√≠msson E, Copeland NG, Jenkins NA, Martin GR, Rutter WJ. Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5870-4. PubMed PMID: 7597044; PubMed Central PMCID: PMC41603.
68: LaBonne C, Burke B, Whitman M. Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development. Development. 1995 May;121(5):1475-86. PubMed PMID: 7789277.
69: Johansson BM, Wiles MV. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol. 1995 Jan;15(1):141-51. PubMed PMID: 7799920; PubMed Central PMCID: PMC231923.
70: Ma√©no M, Ong RC, Suzuki A, Ueno N, Kung HF. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10260-4. PubMed PMID: 7937937; PubMed Central PMCID: PMC44999.
71: Trainor PA, Tan SS, Tam PP. Cranial paraxial mesoderm: regionalisation of cell fate and impact on craniofacial development in mouse embryos. Development. 1994 Sep;120(9):2397-408. PubMed PMID: 7956820.
72: Vidricaire G, Jardine K, McBurney MW. Expression of the Brachyury gene during mesoderm development in differentiating embryonal carcinoma cell cultures. Development. 1994 Jan;120(1):115-22. PubMed PMID: 8119120.
73: George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development. 1993 Dec;119(4):1079-91. PubMed PMID: 8306876.
74: Smith JC. Mesoderm-inducing factors in early vertebrate development. EMBO J. 1993 Dec;12(12):4463-70. Review. PubMed PMID: 8223456; PubMed Central PMCID: PMC413870.
75: Brookman JJ, Toosy AT, Shashidhara LS, White RA. The 412 retrotransposon and the development of gonadal mesoderm in Drosophila. Development. 1992 Dec;116(4):1185-92. PubMed PMID: 1363543.
76: Kimelman D, Christian JL, Moon RT. Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction. Development. 1992 Sep;116(1):1-9. Review. PubMed PMID: 1483380.
77: Milos NC. Mesoderm and jaw development in vertebrates: the role of growth factors. Crit Rev Oral Biol Med. 1992;4(1):73-91. Review. PubMed PMID: 1457686.
78: Leptin M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 1991 Sep;5(9):1568-76. PubMed PMID: 1884999.
79: Cooke J. Mesoderm-inducing factors and Spemann's organiser phenomenon in amphibian development. Development. 1989 Oct;107(2):229-41. PubMed PMID: 2632222.
80: Cooke J. Xenopus mesoderm induction: evidence for early size control and partial autonomy for pattern development by onset of gastrulation. Development. 1989 Jul;106(3):519-29. PubMed PMID: 2598823.
81: Smith JC. Mesoderm induction and mesoderm-inducing factors in early amphibian development. Development. 1989 Apr;105(4):665-77. Review. PubMed PMID: 2689132.
82: Cooke J, Smith JC. The midblastula cell cycle transition and the character of mesoderm in u.v.-induced nonaxial Xenopus development. Development. 1987 Feb;99(2):197-210. PubMed PMID: 3308407.
83: Turpen JB, Smith PB. Dorsal lateral plate mesoderm influences proliferation and differentiation of hemopoietic stem cells derived from ventral lateral plate mesoderm during early development of Xenopus laevis embryos. J Leukoc Biol. 1985 Sep;38(3):415-27. PubMed PMID: 3861753.
84: Cooke J. Dynamics of the control of body pattern in the development of Xenopus laevis. III. Timing and pattern after u.v. irradiation of the egg and after excision of presumptive head endo-mesoderm. J Embryol Exp Morphol. 1985 Aug;88:135-50. PubMed PMID: 4078527.
85: Chevallier A. Role of the somitic mesoderm in the development of the thorax in bird embryos. II. Origin of thoracic and appendicular musculature. J Embryol Exp Morphol. 1979 Jan;49:73-88. PubMed PMID: 448278.
86: Blackshaw SE, Warner AE. Low resistance junctions between mesoderm cells during development of trunk muscles. J Physiol. 1976 Feb;255(1):209-30. PubMed PMID: 1255515; PubMed Central PMCID: PMC1309241.
87: Chevallier A. [Role of the somitic mesoderm in the development of the rib cage of bird embryos. I. Origin of the sternal component and conditions for the development of the ribs (author's transl)]. J Embryol Exp Morphol. 1975 Apr;33(2):291-311. French. PubMed PMID: 1176848.
88: Mauger A. [The role of somitic mesoderm in the development of dorsal plumage in chick embryos. II. Regionalization of the plumage-forming mesoderm]. J Embryol Exp Morphol. 1972 Oct;28(2):343-66. French. PubMed PMID: 4642992.
89: Mauger A. [The role of somitic mesoderm in the development of dorsal plumage in chick embryos. I. Origin, regulative capacity and determination of the plumage-forming mesoderm]. J Embryol Exp Morphol. 1972 Oct;28(2):313-41. French. PubMed PMID: 4642991.
90: Florian J. The Early Development of Man, with Special Reference to the Development of the Mesoderm and Cloacal Membrane. J Anat. 1933 Jan;67(Pt 2):263-76. PubMed PMID: 17104422; PubMed Central PMCID: PMC1249344.