Talk:Embryology History - Robert Edwards

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Cite this page: Hill, M.A. (2019, April 21) Embryology Embryology History - Robert Edwards. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Embryology_History_-_Robert_Edwards


2008

From embryonic stem cells to blastema and MRL mice

Reprod Biomed Online. 2008 Mar;16(3):425-61.

Edwards RG. Source Reproductive BioMedicine Online, Park Lane, Dry Drayton, Cambridge CB3 8DB, UK. rge@rbmonline.com

Abstract

New scientific knowledge offers fresh opportunities for regenerative medicine and tissue repair. Among various clinical options, multipotent embryonic stem cells (ESC) prepared from inner cell masses of rabbit blastocysts have been tested over many years. More recently, stem cells have been isolated from individual tissues and from umbilical cord blood. These methods seemingly offer similar rates of repair and avoid ethical complexities arising from the need for human embryos to prepare ESC. Different methods of regenerating tissues have now emerged, based on the well-known forms of organ regeneration in urodeles such as salamanders. These methods depend on the formation of a blastema, and recent studies on MRL mice have revealed that they possess similar methods of repair as in salamanders. There is also some evidence showing that this form of repair is also active in human fetuses but not in adults. Detailed knowledge of these various forms of tissue repair is now urgently needed in order to assess the benefits of each form of treatment. These matters are discussed at the end of this review where various investigations clarify the benefits and drawbacks of these varied approaches to tissue repair.

PMID 18339268


1981

Test-tube babies, 1981

Nature. 1981 Sep 24;293(5830):253-6.

Edwards RG.

Abstract

Between fifteen and twenty babies will be born this year after the in vitro fertilization of human eggs. Many of the essential steps now have high rates of success, including the recovery of preovulatory oocytes, and fertilization and embryo cleavage in vitro. Implantation of the embryo following its replacement in the mother remains the major difficulty. Some implications of the work are discussed.

PMID 7278985

1978

The primate blastocyst and its environment

Ups J Med Sci Suppl. 1978;22:39-50.

Edwards RG, Surani MA.

PMID 349816

1975

Ultrastructural relationships between decidua, trophoblast and lymphocytes at the beginning of human pregnancy

J Reprod Fertil. 1975 Mar;42(3):431-8.

Tekelioğlu-Uysal M, Edwards RG, Kişnişçi HA.

Abstract

Between the 20th and 40th day of pregnancy, human decidual cells in the endometrial connective tissue come into direct contact with the trophoblastic cells eroding the stromal tissue. Fibrillar deposits of maternal origin were randomly distributed between the maternal and fetal sites and did not form a continuous barrier. Structural features were prominent in the maternal and embryonic cells. Large decidual cells were intermingled with trophoblastic cells, and there was little intercellular material. Small developing decidual cells arose around the maternal precapillary arterioles and capillaries and were closely accompanied by lymphocytes. Fully developed decidual cells exhibited a fine structure characteristic of a state of active secretion, and trophoblastic cells gave structural indications of producing protein. The aggregates of decidual and trophoblastic cells in the human endometrium during early pregnancy ('deciduotrophoblastic complex') may function as a local humoral regulator releasing chemical factors and partaking in the establishment of immunological privilege at implantation.

PMID 164546

1974

Follicular fluid

J Reprod Fertil. 1974 Mar;37(1):189-219.

Edwards RG.

PMID 4274030

http://www.reproduction-online.org/content/37/1/189.long

1969

Immunological aspects of infertility

Proc R Soc Med. 1969 Jan;62(1):25-6.

Edwards RG.

PMID 4178888

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279076

1966

Mammalian eggs in the laboratory

Sci Am. 1966 Aug;215(2):72-81.

Edwards RG.

PMID 5949880

1965

Maturation in vitro of human ovarian oöcytes

Edwards RG.

Lancet. 1965 Nov 6;2(7419):926-9. No abstract available.

PMID 4165802


Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes

Edwards RG.

Nature. 1965 Oct 23;208(5008):349-51. No abstract available.

PMID 4957259

http://www.nature.com/nature/journal/v208/n5008/pdf/208349a0.pdf

1961

Analysis of differences in the numbers of eggs shed by the two ovaries of mice during natural oestrus or after superovulation

FALCONER DS, EDWARDS RG, FOWLER RE, ROBERTS RC.

J Reprod Fertil. 1961 Nov;2:418-37. No abstract available.

PMID 13891417

http://www.reproduction-online.org/content/2/4/418.long

1957

Duration of spermatogenesis in the mouse

Nature. 1957 Nov 23;180(4595):1138-9.

SIRLIN JL, EDWARDS RG.

PMID 13483641

http://www.nature.com/nature/journal/v179/n4562/index.html

http://www.nature.com/nature/journal/v179/n4562/pdf/179725b0.pdf


Induction of superovulation and pregnancy in mature mice by gonadotrophins

J Endocrinol. 1957 Sep;15(4):374-84.

FOWLER RE, EDWARDS RG.

PMID 13475597

http://joe.endocrinology-journals.org/content/15/4/374.abstract

1955

Selective fertilization following the use of sperm mixtures in the mouse

Nature. 1955 Jan 29;175(4448):215-6.

EDWARDS RG.

PMID 13235857