Talk:Embryology History - Robert Edwards
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Cite this page: Hill, M.A. (2019, October 16) Embryology Embryology History - Robert Edwards. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Embryology_History_-_Robert_Edwards
From embryonic stem cells to blastema and MRL mice
Reprod Biomed Online. 2008 Mar;16(3):425-61.
Edwards RG. Source Reproductive BioMedicine Online, Park Lane, Dry Drayton, Cambridge CB3 8DB, UK. email@example.com
New scientific knowledge offers fresh opportunities for regenerative medicine and tissue repair. Among various clinical options, multipotent embryonic stem cells (ESC) prepared from inner cell masses of rabbit blastocysts have been tested over many years. More recently, stem cells have been isolated from individual tissues and from umbilical cord blood. These methods seemingly offer similar rates of repair and avoid ethical complexities arising from the need for human embryos to prepare ESC. Different methods of regenerating tissues have now emerged, based on the well-known forms of organ regeneration in urodeles such as salamanders. These methods depend on the formation of a blastema, and recent studies on MRL mice have revealed that they possess similar methods of repair as in salamanders. There is also some evidence showing that this form of repair is also active in human fetuses but not in adults. Detailed knowledge of these various forms of tissue repair is now urgently needed in order to assess the benefits of each form of treatment. These matters are discussed at the end of this review where various investigations clarify the benefits and drawbacks of these varied approaches to tissue repair.
Test-tube babies, 1981
Nature. 1981 Sep 24;293(5830):253-6.
Between fifteen and twenty babies will be born this year after the in vitro fertilization of human eggs. Many of the essential steps now have high rates of success, including the recovery of preovulatory oocytes, and fertilization and embryo cleavage in vitro. Implantation of the embryo following its replacement in the mother remains the major difficulty. Some implications of the work are discussed.
The primate blastocyst and its environment
Ups J Med Sci Suppl. 1978;22:39-50.
Edwards RG, Surani MA.
Ultrastructural relationships between decidua, trophoblast and lymphocytes at the beginning of human pregnancy
J Reprod Fertil. 1975 Mar;42(3):431-8.
Tekelioğlu-Uysal M, Edwards RG, Kişnişçi HA.
Between the 20th and 40th day of pregnancy, human decidual cells in the endometrial connective tissue come into direct contact with the trophoblastic cells eroding the stromal tissue. Fibrillar deposits of maternal origin were randomly distributed between the maternal and fetal sites and did not form a continuous barrier. Structural features were prominent in the maternal and embryonic cells. Large decidual cells were intermingled with trophoblastic cells, and there was little intercellular material. Small developing decidual cells arose around the maternal precapillary arterioles and capillaries and were closely accompanied by lymphocytes. Fully developed decidual cells exhibited a fine structure characteristic of a state of active secretion, and trophoblastic cells gave structural indications of producing protein. The aggregates of decidual and trophoblastic cells in the human endometrium during early pregnancy ('deciduotrophoblastic complex') may function as a local humoral regulator releasing chemical factors and partaking in the establishment of immunological privilege at implantation.
J Reprod Fertil. 1974 Mar;37(1):189-219.
Immunological aspects of infertility
Proc R Soc Med. 1969 Jan;62(1):25-6.
Mammalian eggs in the laboratory
Sci Am. 1966 Aug;215(2):72-81.
Maturation in vitro of human ovarian oöcytes
Lancet. 1965 Nov 6;2(7419):926-9. No abstract available.
Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes
Nature. 1965 Oct 23;208(5008):349-51. No abstract available.
Analysis of differences in the numbers of eggs shed by the two ovaries of mice during natural oestrus or after superovulation
FALCONER DS, EDWARDS RG, FOWLER RE, ROBERTS RC.
J Reprod Fertil. 1961 Nov;2:418-37. No abstract available.
Duration of spermatogenesis in the mouse
Nature. 1957 Nov 23;180(4595):1138-9.
SIRLIN JL, EDWARDS RG.
Induction of superovulation and pregnancy in mature mice by gonadotrophins
J Endocrinol. 1957 Sep;15(4):374-84.
FOWLER RE, EDWARDS RG.
Selective fertilization following the use of sperm mixtures in the mouse
Nature. 1955 Jan 29;175(4448):215-6.