Talk:Developmental Mechanism - Cell Migration

From Embryology
About Discussion Pages  
Mark Hill.jpg
On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes:
  1. References - recent and historic that relates to the topic
  2. Additional topic information - currently prepared in draft format
  3. Links - to related webpages
  4. Topic page - an edit history as used on other Wiki sites
  5. Lecture/Practical - student feedback
  6. Student Projects - online project discussions.
Links: Pubmed Most Recent | Reference Tutorial | Journal Searches

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2019, October 18) Embryology Developmental Mechanism - Cell Migration. Retrieved from


LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development

Dev Biol. 2016 Aug 12. pii: S0012-1606(16)30104-X. doi: 10.1016/j.ydbio.2016.08.006. [Epub ahead of print]

Creuzet S1, Viallet J2, Ghawitian M2, Torch S2, Thélu J2, Alrajeh M3, Radu A2, Bouvard D2, Costagliola F2, Borgne ML2, Buchet-Poyau K2, Aznar N2, Buschlen S3, Hosoya H4, Thibert C5, Billaud M6.


Head development in vertebrates proceeds through a series of elaborate patterning mechanisms and cell-cell interactions involving cephalic neural crest cells (CNCC). These cells undergo extensive migration along stereotypical paths after their separation from the dorsal margins of the neural tube and they give rise to most of the craniofacial skeleton. Here, we report that the silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory CNCC from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects. We further show that LKB1-mediated effects on the development of CNCC involve the sequential activation of the AMP-activated protein kinase (AMPK), the Rho-dependent kinase (ROCK) and the actin-based motor protein myosin II. Collectively, these results establish that the complex morphogenetic processes governing head formation critically depends on the activation of the LKB1 signaling network in CNCC. Copyright © 2016. Published by Elsevier Inc. KEYWORDS: AMPK; Lkb1; actin dynamic; cell polarity; cephalic neural crest cells; head development

PMID 27527806

Collective cell migration in development

J Cell Biol. 2016 Jan 18;212(2):143-55. doi: 10.1083/jcb.201508047.

Scarpa E1, Mayor R2.


During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migration. The molecular and biomechanical mechanisms underlying collective migration of developing tissues have been investigated in a variety of models, including border cell migration, tracheal branching, blood vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mesendoderm. Here we review recent advances in understanding collective migration in these developmental models, focusing on the interaction between cells and guidance cues presented by the microenvironment and on the role of cell-cell adhesion in mechanical and behavioral coupling of cells within the collective. © 2016 Scarpa and Mayor.

PMID 26783298