Talk:Coelomic Cavity Development
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Cite this page: Hill, M.A. (2019, December 9) Embryology Coelomic Cavity Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Coelomic_Cavity_Development
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Human coelomic fluid investigation: A MS-based analytical approach to prenatal screening
Aiello D, Giambona A, Leto F, Passarello C, Damiani G, Maggio A, Siciliano C & Napoli A. (2018). Human coelomic fluid investigation: A MS-based analytical approach to prenatal screening. Sci Rep , 8, 10973. PMID: 30030477 DOI.
Aiello D1, Giambona A2, Leto F2, Passarello C2, Damiani G3, Maggio A2, Siciliano C4, Napoli A5. Author information Abstract Coelomic fluid (CF) is the earliest dynamic and complex fluid of the gestational sac. CF contains maternal cells and proteins produced by embryonic cells, tissues and excretions. The biochemical composition of CF is modified throughout the first trimester of pregnancy and its protein profile reflects both physiological/pathological changes affecting the embryo and mother. Identification of variations in the balance of proteins might indicate particular types of pathologies, or ascertain specific genetic disorders. A platform utilizing protein enrichment procedures coupled with shotgun identification and iTRAQ differentiation provided the identification and quantitation of 88 unique embryonic proteins. It is relevant to note that chromosome X protein CXorf23 was found suggesting the embryo sex. Foetal sex was determined by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) on coelomic cells, foetal tissues and maternal white blood cells, with a 100% concordance rate between iTRAQ-MS/MS and QF-PCR data. The functional associations among the identified proteins were investigated using STRING database. Open Targets Platform showed as significant the following therapeutic areas: nervous, respiratory, eye and head system disease.
PMID: 30030477 PMCID: PMC6054674 DOI: 10.1038/s41598-018-29384-9
Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities
Koopmans T1, Rinkevich Y1.
The internal organs embedded in the cavities are lined by an epithelial monolayer termed the mesothelium. The mesothelium is increasingly implicated in driving various internal organ pathologies, as many of the normal embryonic developmental pathways acting in mesothelial cells, such as those regulating epithelial-to-mesenchymal transition, also drive disease progression in adult life. Here, we summarize observations from different animal models and organ systems that collectively point toward a central role of epithelial-to-mesenchymal transition in driving tissue fibrosis, acute scarring, and cancer metastasis. Thus, drugs targeting pathways of mesothelium's transition may have broad therapeutic benefits in patients suffering from these diseases. PMID: 30345394 PMCID: PMC6191446 DOI: 10.1038/s42003-018-0180-x
Mesothelial-mesenchymal transitions in embryogenesis
Carmona R1, Ariza L1, Cano E2, Jiménez-Navarro M3, Muñoz-Chápuli R4. Author information Abstract Most animals develop coelomic cavities lined by an epithelial cell layer called the mesothelium. Embryonic mesothelial cells have the ability to transform into mesenchymal cells which populate many developing organs contributing to their connective and vascular tissues, and also to organ-specific cell types. Furthermore, embryonic mesothelium and mesothelial-derived cells produce essential signals for visceral morphogenesis. We review the most relevant literature about the mechanisms regulating the embryonic mesothelial-mesenchymal transition, the developmental fate of the mesothelial-derived cells and other functions of the embryonic mesothelium, such as its contribution to the establishment of left-right visceral asymmetries or its role in limb morphogenesis. Copyright © 2018 Elsevier Ltd. All rights reserved. KEYWORDS: Coelomic epithelium; Epithelial-mesenchymal transition; Mesothelium; Organogenesis PMID: 30243860 DOI: 10.1016/j.semcdb.2018.09.006
Coelomic epithelium-derived cells in visceral morphogenesis
Dev Dyn. 2016 Mar;245(3):307-22. doi: 10.1002/dvdy.24373. Epub 2015 Dec 28.
Ariza L1,2, Carmona R1,2, Cañete A1,2, Cano E3, Muñoz-Chápuli R1,2.
Coelomic cavities of vertebrates are lined by a mesothelium which develops from the lateral plate mesoderm. During development, the coelomic epithelium is a highly active cell layer, which locally is able to supply mesenchymal cells that contribute to the mesodermal elements of many organs and provide signals which are necessary for their development. The relevance of this process of mesenchymal cell supply to the developing organs is becoming clearer because genetic lineage tracing techniques have been developed in recent years. Body wall, heart, liver, lungs, gonads, and gastrointestinal tract are populated by cells derived from the coelomic epithelium which contribute to their connective and vascular tissues, and sometimes to specialized cell types such as the stellate cells of the liver, the Cajal interstitial cells of the gut or the Sertoli cells of the testicle. In this review we collect information about the contribution of coelomic epithelium derived cells to visceral development, their developmental fates and signaling functions. The common features displayed by all these processes suggest that the epithelial-mesenchymal transition of the embryonic coelomic epithelium is an underestimated but key event of vertebrate development, and probably it is shared by all the coelomate metazoans. © 2015 Wiley Periodicals, Inc. KEYWORDS: Wilms' tumor suppressor gene; coelomic epithelium; epicardium; epithelial-mesenchymal transitions; mesothelium
Embryo-fetal erythroid megaloblasts in the human coelomic cavity
J Cell Physiol. 2010 Nov;225(2):385-9.
Renda MC, Giambona A, Fecarotta E, Leto F, Makrydimas G, Renda D, Damiani G, Jakil MC, Picciotto F, Piazza A, Valtieri M, Maggio A. Source Hematology II-Thalassemia, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
The coelomic cavity is part of the extraembryonic mesoderm, surrounding amniotic cavity, embryo, and yolk sac in the early gestation. It is now believed to represent an important transfer interface and a reservoir of nutrients for the embryo. Coelocentesis by ultrasound-guided transvaginal puncture offers an easier access to the early human embryo, from 28 days post-fertilization. However, despite some studies about its biochemical composition being reported, our knowledge about the presence of cellular elements and their quality in this compartment are still limited. Here we studied human coelomic fluids sampled from 6.6 (48 days) to 10 weeks of gestation, demonstrating the presence of functional embryonic erythroid precursors, that is, megaloblasts in the coelomic cavity. The ease of access of the coelomic cavity could allow the development of novel strategies for diagnostic or therapeutic purposes by ultrasound imaging and ultrasound-guided puncture.
(c) 2010 Wiley-Liss, Inc.
Fluid compartments of the embryonic environment
Hum Reprod Update. 2000 May-Jun;6(3):268-78.
Jauniaux E, Gulbis B.
The exocoelomic cavity was probably the last remaining physiological body fluid cavity to be explored in the human embryo. Its unique anatomical position has enabled us to study the protein metabolism of the early placenta and secondary yolk sac and to explore materno-embryonic transfer pathways. The exocoelomic cavity forms inside the extraembryonic mesoderm alongside the placental chorionic plate and is now believed to be an important transfer interface and a reservoir of nutrients for the embryo. Maternal or placental proteins filtered in the extraembryonic coelomic cavity are probably absorbed by the secondary yolk sac which is directly connected with the primitive digestive system throughout embryonic development. Protein electrophoresis has shown that the coelomic fluid results from an ultrafiltrate of maternal serum with the addition of specific placental and secondary yolk sac bioproducts demonstrating that the exocoelomic cavity is a physiological liquid extension of the early placenta. The selective sampling of fluid from the exocoelomic cavity has also offered a novel approach to the study of drug and toxin transfer across the early human placenta and as a unique tool to explore embryonic physiology in vivo. Further investigation should include a comparison between the coelomic fluid values of a molecule and its quantifiable presence in decidual, placental and fetal tissues.
Coelom formation: binary decision of the lateral plate mesoderm is controlled by the ectoderm
Development. 1999 Sep;126(18):4129-38.
Funayama N, Sato Y, Matsumoto K, Ogura T, Takahashi Y.
Most triploblastic animals including vertebrates have a coelomic cavity that separates the outer and inner components of the body. The coelom is lined by two different tissue components, somatopleure and splanchnopleure, which are derived from the lateral plate region. Thus, the coelom is constructed as a result of a binary decision during early specification of the lateral plate. In this report we studied the molecular mechanisms of this binary decision. We first demonstrate that the splitting of the lateral plate into the two cell sheets progresses in an anteroposterior order and this progression is not coordinated with that of the somitic segmentation. By a series of embryological manipulations we found that young splanchnic mesoderm is still competent to be respecified as somatic mesoderm, and the ectoderm overlying the lateral plate is sufficient for this redirection. The lateral ectoderm is also required for maintenance of the somatic character of the mesoderm. Thus, the ectoderm plays at least two roles in the early subdivision of the lateral plate: specification and maintenance of the somatic mesoderm. We also show that the latter interactions are mediated by BMP molecules that are localized in the lateral ectoderm. Evolutionary aspects of the coelom formation are also considered.