Talk:Abnormal Development - Lymphocytic Choriomeningitis Virus

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Cite this page: Hill, M.A. (2019, June 26) Embryology Abnormal Development - Lymphocytic Choriomeningitis Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Lymphocytic_Choriomeningitis_Virus

2009

Immunopathological basis of lymphocytic choriomeningitis virus-induced chorioretinitis and keratitis

J Virol. 2009 Jan;83(1):159-66. Epub 2008 Oct 22.

Zinkernagel MS, Bolinger B, Krebs P, Onder L, Miller S, Ludewig B. Source Research Department, Kantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland.

Abstract

The infection of humans with the rodent-borne lymphocytic choriomeningitis virus (LCMV) can lead to central nervous system disease in adults or severe neurological disease with hydrocephalus and chorioretinitis in children infected congenitally. Although LCMV-induced meningitis and encephalitis have been studied extensively, the immunopathological mechanisms underlying LCMV infection-associated ocular disease remain elusive. We report here that the intraocular administration of the neurotropic LCMV strain Armstrong (Arm) elicited pronounced chorioretinitis and keratitis and that infection with the more viscerotropic strains WE and Docile precipitated less severe immunopathological ocular disease. Time course analyses revealed that LCMV Arm infection of the uvea and neuroretina led to monophasic chorioretinitis which peaked between days 7 and 12 after infection. Analyses of T-cell-deficient mouse strains showed that LCMV-mediated ocular disease was strictly dependent on the presence of virus-specific CD8(+) T cells and that the contribution of CD4(+) T cells was negligible. Whereas the topical application of immunosuppressive agents did not prevent the development of chorioretinitis, passive immunization with hyperimmune sera partially prevented retinal and corneal damage. Likewise, mice displaying preexisting LCMV-specific T-cell responses were protected against LCMV-induced ocular disease. Thus, antibody- and/or T-cell-based vaccination protocols could be employed as preventive strategies against LCMV-mediated chorioretinitis.

PMID 18945766


2006

Lymphocytic choriomeningitis virus: an emerging obstetric pathogen?

Am J Obstet Gynecol. 2006 Jun;194(6):1532-6. Epub 2006 Apr 21.

Jamieson DJ, Kourtis AP, Bell M, Rasmussen SA. Source Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Abstract

A report in May 2005 from the Centers for Disease Control and Prevention describing a cluster of lymphocytic choriomeningitis virus (LCMV) infections among 4 solid organ recipients has increased awareness of and clinical interest in this pathogen. Human infection with LCMV results from direct or indirect contact with rodents. LCMV has particular relevance to obstetrics, as it is likely an under-recognized abortifacient and fetal teratogen. There have been 54 cases of congenital LCMV reported since 1955, with 34 of the cases diagnosed since 1993. Chorioretinitis and hydrocephalus are the predominant characteristics among children diagnosed with congenital LCMV infection. Obstetricians should educate their pregnant patients about the risks of exposure to laboratory, pet, and wild rodents.

PMID 16731068

2002

Lymphocytic choriomeningitis virus: emerging fetal teratogen

Am J Obstet Gynecol. 2002 Dec;187(6):1715-6.

Barton LL, Mets MB, Beauchamp CL. Source Department of Pediatrics and Steele Memorial Children's Research Center, University of Arizona, Tucson 85724, USA. llb@peds.arizona.edu Abstract Lymphocytic choriomeningitis virus (LCMV), a rodent-borne arenavirus, is an often undiagnosed human fetal teratogen. We describe a neonate born with hydrocephalus and chorioretinitis after maternal second-trimester symptomatic LCMV infection. Previously reported affected infants are reviewed. We strongly suggest that obstetricians counsel their pregnant patients regarding the potential hazard that contact with infected pet, laboratory, and household mice and hamsters poses to pregnant women and their unborn children.

PMID 12501090