Somitogenesis Molecular Movie

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Molecular Patterning of Presomitic Mesoderm

This imaging of the early mouse embryo shows the localised expression in mesoderm of the transcription factor Hes1 that cycles coordinately preceding the formation of new somite pairs in a rostro-cauldal direction.


Realtime expression of Hes1 in presomitic mesoderm (PSM) in the mouse embryo. Embryonic day E10.5 Hes1-Ub1-Luc embryo. Images were taken by 20-min exposure and binning of pixels 4 × 4 over a period of 15 h. Oscillation was propagated from the caudal end to S0 in the PSM."


Links: MP4 version | Somitogenesis | Mesoderm | Molecular Development

Somitogenesis 01 icon.jpg Mesoderm Hes1.jpg

Model for Sprouty4 and FGF in mesoderm segmentation

About Hes1

  • Hairy/Enhancer of Split (Drosophila), Homolog of, 1; HES1
  • basic helix-loop-helix (bHLH) protein
  • transcription factor


Reference

Yoshito Masamizu, Toshiyuki Ohtsuka, Yoshiki Takashima, Hiroki Nagahara, Yoshiko Takenaka, Kenichi Yoshikawa, Hitoshi Okamura, Ryoichiro Kageyama Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc. Natl. Acad. Sci. U.S.A.: 2006, 103(5);1313-8 PubMed 16432209

| PNAS


Copyright

Proceedings National Academy of Sciences (PNAS) Liberalization of PNAS copyright policy: Noncommercial use freely allowed Note original Author should be contacted for permission to reuse for Educational purposes. See also PNAS Author Rights and Permission FAQs

Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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Cite this page: Hill, M.A. 2017 Embryology Somitogenesis Molecular Movie. Retrieved September 25, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Somitogenesis_Molecular_Movie

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© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G [Category:Molecular]]