Paper - Normal and abnormal development of human embryos

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Nishimura H. Takano K. Tanimura T, and Yasuda M. Normal and abnormal development of human embryos: First report of the analysis of 1,213 intact embryos. (1968) Teratology, 1: 281-290. PubMed 5759548

Online Editor Note  
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This historic 1968 paper by Nishimura and colleagues describes human embryos from the Kyoto Collection.

Nishimura H. Tanimura T. Semba R. Uwabe C. Normal development of early human embryos: Observation of 90 specimens at Carnegie stages 7 to 13. (1974)Teratology 10(1): 1-5. PubMed 4853372

Modern Notes:
Kyoto Collection



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Normal and Abnormal Development of Human Embryos: First Report of the Analysis of 1,213 Intact Embryos

Hideo Nishimura (1912–1995)
Hideo Nishimura (1912–1995)

Abstract

This survey of the development of a large number of virtually unselected human embryos from healthy women allowed us to establish more reliable standards of normal development with respect to crown-rump length, body weight, and external form than those usually cited. Remarkable variation was noted with regard to the relation between clinical age and these attributes and thus it is concluded that crown-rump length and body weight are more reliable indicators of the general state of development than clinically established age.


Dead embryos occurred with a significantly greater frequency in women with a history of genital bleeding during pregnancy than in those without. Externally malformed embryos were found with increasing frequency with advancing developmental stage, with the maximum figure of 3.92% at horizons 19–23. Malformations observed included external defects such as exencephaly, cyclopia, myeloschisis, cleft lip, and several limb malformations. It is of considerable interest that the incidence of most of these defects was far higher than that observed in newborn infants.


Literature Cited

Aoki, H. 1962 On notified induced abortions in Japan. Annual Reports of the Institute of Population Problems, Ministry of Health and Welfare, Japan, 7: 45—52. (In Japanese.)

Arey, L. B. 1965 Developmental Anatomy. Saunders, Philadelphia.

Hellmann, K. 1966 Immunosuppression by thalidomide: Implications for teratology. Lancet, 1: 1136-1137.

Iffy, L., T. H. Shepard, A. Jakobovits, R. J. Lemire, and P. Kerner 1967 The rate of growth in young embryos of Streeter’s horizons XIII to XXIII. Acta Anat., 66: 178-186.

Jirasek, J. E., J. Uher, and M. Uhrova 1966 Water and nitrogen content of the body of young human embryos. Am. J. Obstet. Gynec., 96: 861-871.

Mitani, S. 1954 Malformations of the newborn infants. J. Jap. Obstet. Gynec. Soc., 1: 301-315. Nakamura, K., O. Saito, and T. Cho 1955 Measurements of early Japanese embryos. F.irst Report: Body length and body Weight.

Bull. Kobe Med. Coll., 6: 113-117. (In Japanese.) Neel, J. M. 1958 A study of major congenital defects in Japanese infants. Am. J. Hum. Genet., 10: 398-445.

Nishimura H. Takano K. Tanimura T. Yasuda M. and Uchida T. High incidence of several malformations in the early human embryos as compared with infants. (1966) Biol. Neonat, 10: 93-107. PMID 5919856

Patten, B. M. 1953 Human McGraw-Hill, New York.

Pearson, A. A., H. Nishimura, T. Tanimura, and R. W. Sauter 1968 Observations on the development of the external form of the Japanese embryo. Anat. Rec., 160: (Abstract) 489-490.

Section of Statistics in The Secretariat of Ministry of Health and Welfare, Japan. 1963 Statistics on Eugenie Protection in Japan, 1963. Ministry of Health and Welfare, Japan, Tokyo. (In Japanese.)

Shimamura, A. 1957 Age determination and physical measurements of Japanese embryo. Jap. J. Leg. Med., 11: 795-811. (In Japanese.)


Stevenson AC. Johnston HA. Stewart MI. and Golding DR. Congenital malformations. A report of a study of series of consecutive births in 24 centres. (1966) Bull World Health Organ. 34 Suppl: 9-11. PMID 5296840

Streeter GL. Developmental horizons in human embryos. Description of age group XI, 13 to 20 somites, and age group XII, 21 to 29 somites. (1942) Contrib. Embryol., Carnegie Inst. Wash. Publ. 541, 30: 211-245.

Streeter GL. Developmental horizons in human embryos. Description of age group XIII, embryos about 4 or 5 millimeters long, and age group XIV, period of indentation of the lens vesicle. (1945) Carnegie Instn. Wash. Publ. 557, Contrib. Embryol., Carnegie Inst. Wash., 31: 27-63.

Streeter GL. Developmental horizons in human embryos. Description of age groups XV, XVI, XVII, and XVIII, being the third issue of a survey of the Carnegie collection. (1948) Contrib. Embryol., Carnegie Inst. Wash. 575, 32: 133-203.

Streeter GL. Developmental horizons in human embryos. Description of age groups XIX, XX, XXI, XXII, and XXIII, being the fifth issue of a survey of the Carnegie Collection (prepared for publication by Heuser CH. and Corner GW.). (1951) Carnegie Instn. Wash. Publ. 592, Contrib. Embryol., 34: 165-196.

Takakusu, A., and T. Ban 1963 On the age of Japanese embryos. Med. J. Osaka Univ., 13.285-291.

Witschi E. Development of Vertebrates. (1956) Saunders, Philadelphia.



Cite this page: Hill, M.A. (2019, October 23) Embryology Paper - Normal and abnormal development of human embryos. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Normal_and_abnormal_development_of_human_embryos

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