File:Model for immune role in implantation - Mucin absence.jpg

Model for Immune role in Implantation

Proposed model for antigen-presenting cells and decidual lymphocytes interactions at the maternal-foetal interface in the absence of mucin-1- (Muc 1-) and tumour-associated glycoprotein-72 (TAG-72).

• The functions of dendritic cells (DCs) and macrophages (Mfgs) may be influenced by Muc 1 and TAG-72 that bind to the mannose receptor (MR) and CD209. TAG-72-shaped DCs may produce less CD83, resulting in lower proliferation and selective apoptosis of cognate cytotoxic T cells to allow survival of Th2-oriented T cells with low production of IFN-gamma (IFN-γ), attracted by CC chemokine ligand- (CCL-)19 and CCL22.
• Mfgs in the presence of TAG-72 produced higher levels of interleukin (IL)-10 and IL-1 receptor antagonist (IL-1RA), but significantly decreased levels of IL-12 and CCL3, support a Th2 bias. Muc 1-shaped Mfgs increased IL-1 receptor type II (IL-1R type II) expression, whereas a D6 decoy, CD80, CD86, and human leukocyte antigen (HLA)DR remain relatively unchanged.
• Muc 1-shaped Mfgs and TAG-72-treated DCs appear to decrease IL-15 production and cannot support the proliferation of CD56 bright NK cells and expression of cytotoxic mediators.
• Low IFN-γ expression by TAG-treated DCs does not support decidual vessel remodelling.
• During normal eutopic implantation, removing surface epithelial glycoproteins (b) allows antigen-presenting cells to support mild proinflammatory reactions by increasing IL-15 and IFN-γ production and amplifying NK cells, which are rich in cytotoxic mediators.

Links: Model with Mucin | Model without Mucin | Implantation

Reference

<pubmed>23864879</pubmed>| Clin Dev Immunol.

Copyright

© 2013 Arnela Redzovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 1 542152.fig.001a.jpg http://www.hindawi.com/journals/jir/2013/542152/fig1/#a