File:Human fetal neural aneuploidy.jpg

Human Fetal Neural Aneuploidy

Molecular cytogenetic analysis of aneuploidy in the fetal human brain. (A to C). Interphase FISH with chromosome-enumeration DNA probes: (A) two nuclei characterized by additional chromosomes Y and X and a normal nucleus; (B) a nucleus with monosomy of chromosome 15 and a normal nucleus; (C) a nucleus with monosomy of chromosome 18 and a normal nucleus. (D to G) interphase chromosome-specific MCB: nuclei with monosomy, disomy, trisomy and G-banding ideograms with MCB color-code labeling of a chromosome (from left to right), (D) - chromosome 9, (E) - chromosome 16, and (F) - chromosome 18. (G) interphase QFISH: (1) a nucleus with two signals for chromosomes 18 (relative intensities: 2058 and 1772 pixels), (2) a nucleus with one paired signal mimics monosomy of chromosome 18 (relative intensity: 4012 pixels), (3) a nucleus with two signals for chromosomes 15 (relative intensities: 1562 and 1622 pixels), (4) a nucleus with one signal showing monosomy of chromosome 15 (relative intensity: 1678 pixels).

Links: Monosomy | Abnormal Development - Genetic | Neural System Development

Reference

<pubmed>17593959</pubmed>| PMC1891435 | PLoS One.

Copyright

© 2007 Yurov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Yurov YB, Iourov IY, Vorsanova SG, Liehr T, Kolotii AD, Kutsev SI, et al. (2007) Aneuploidy and Confined Chromosomal Mosaicism in the Developing Human Brain. PLoS ONE 2(6): e558. doi:10.1371/journal.pone.0000558

doi:10.1371/journal.pone.0000558.g001

Journal.pone.0000558.g001.jpg