Coelomic Cavity Development
|Embryology - 22 Jul 2017 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Objectives
- 4 Development Overview
- 5 Extraembryonic Coelom
- 6 Intra-embryonic Coelom
- 7 Week 8
- 8 Mesentery and Retroperitoneal
- 9 Mesothelium
- 10 References
- 11 Additional Images
- 12 Terms
- 13 Glossary Links
- coelom - (Greek, koilma = cavity) Term used to describe a fluid-filled cavity or space. Placental vertebrate development have both extraembryonic (outside the embryo) and intraembryonic (inside the embryo) coeloms.
The extra-embryonic coeloms include the yolk sac, amniotic cavity and the chorionic cavity information on these spaces can also be found on placental development pages.
The intra-embryonic coelom is initially a single space located in the lateral plate mesoderm, that will later form the 3 major body cavities: pleural, pericardial and peritoneal.
All intra-embryonic cavities are fluid filled and developing organs push against a wall of the cavity, generating a double coat (serosal/adventital) surrounding an organ (for example the lungs). The serous membrane is the epithelium (squamous) and its associated underlying loose connective tissue.
|Coelom Links: Introduction | Lecture - Week 3 Development | Lecture - Mesoderm Development | Placenta - Membranes | Category:Coelomic Cavity|
|Historic Embryology: 1891 peritoneal | 1910 | 1924 serous|
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Tereza Cindrova-Davies, Eric Jauniaux, Michael G Elliot, Sungsam Gong, Graham J Burton, D Stephen Charnock-Jones RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken. Proc. Natl. Acad. Sci. U.S.A.: 2017; PubMed 28559354
Tony Silveira, Mariana H Remião, Ricardo B Robaldo, Kaio Freitas, Ana Luísa S Valente Prey species of franciscana Pontoporia blainvillei as paratenic hosts of helminths. Dis. Aquat. Org.: 2017, 123(3);251-256 PubMed 28322211
Anca Maria Panaitescu, Fred Ushakov, Anjali Kalaskar, Pranav P Pandya Ultrasound Features and Management of Body Stalk Anomaly. Fetal. Diagn. Ther.: 2016; PubMed 26928926
Mercedes Maceren-Pates, Yoshihisa Kurita, Gaudioso Pates, Michiyasu Yoshikuni A model for germ cell development in a fully segmented worm. Zoological Lett: 2015, 1;34 PubMed 26649187
Augusto Pereira, Elsa Mendizabal, Juan de Leon, Tirso Pérez-Medina, Javier F Magrina, Paul M Magtibay, Ana Rodríguez-Tapia, Santiago Lizarraga, Luís Ortiz-Quintana Peritoneal carcinomatosis: A malignant disease with an embryological origin? Surg Oncol: 2015; PubMed 26141556
- Describe the development of the intra- and extra-embryonic coeloms.
- Describe the processes involved in the development of the three divisions of the intra-embryonic coelom; pericardium, pleural cavities and peritoneum.
- Describe the fate of the extra embryonic coelom.
- Describe the development of the diaphragm.
| Extraembryonic Coelom
|| Intraembryonic Coelom
|| Neural Tube
The fluid-filled (amniotic fluid) extraembryonic coelom (cavity) formed initially by epiblast and then lined by ectoderm and surrounding extraembryonic mesoderm. In humans, it forms the innermost fetal membrane, produces amniotic fluid expanding to eventually fuse with the chorionic membrane during week 8 of development. This fluid-filled sac initially lies above the trilaminar embryo disc and with embryonic disc folding this sac is drawn ventrally to enclose (cover) the entire embryo, then fetus. The presence of this membrane led to the description of reptiles, bird, and mammals as "amniotes".
The fluid-filled extra-embryonic coelom (cavity) formed initially from trophoblast and extra-embryonic mesoderm that forms placenta. Chorion and amnion are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange. In humans, this cavity is lost during week 8 when the amniotic cavity expands and fuses with the chorion.
An extra-embryonic membrane which is endoderm origin and covered with extraembryonic mesoderm. Yolk sac lies outside the embryo connected initially by a yolk stalk to the midgut with which it is continuous with. The endodermal lining is continuous with the endoderm of the gastrointestinal tract. The extra-embryonic mesoderm differentiates to form both blood and blood vessels of the vitelline system. In reptiles and birds, the yolk sac has a function associated with nutrition. In mammals the yolk sac acts as a source of primordial germ cells and blood cells. Note that in early development (week 2) a structure called the "primitive yolk sac" forms from hypoblast, this is an entirely different structure.
Week 5 pericardial and peritoneal cavities
Reflections of the Pleura
Embryo Stage 13 Peritoneal Cavity
Mesentery and Retroperitoneal
Stages in the development of the bursa omentalis, the greater omentum, and the fusion of the latter with the transverse mesocolon.
The epithelial covering of coelomic organs and also line their cavities.
- Contribute to the vasculature of the heart and the intestinal tract.
- Undergo epithelial-mesenchymal transition (EMT), migration, and differentiation into endothelial cells, vascular smooth muscle cells, and pericytes.
- contribute most of the vascular smooth muscle to the respiratory and gastrointestinal tract. (Remainder derived from endothelium?)
- Laura Ariza, Rita Carmona, Ana Cañete, Elena Cano, Ramón Muñoz-Chápuli Coelomic epithelium-derived cells in visceral morphogenesis. Dev. Dyn.: 2015; PubMed 26638186
- Maria Concetta Renda, Antonino Giambona, Emanuela Fecarotta, Filippo Leto, George Makrydimas, Disma Renda, Gianfranca Damiani, Maria Cristina Jakil, Francesco Picciotto, Angela Piazza, Mauro Valtieri, Aurelio Maggio Embryo-fetal erythroid megaloblasts in the human coelomic cavity. J. Cell. Physiol.: 2010, 225(2);385-9 PubMed 20533375
Laura Ariza, Rita Carmona, Ana Cañete, Elena Cano, Ramón Muñoz-Chápuli Coelomic epithelium-derived cells in visceral morphogenesis. Dev. Dyn.: 2015; PubMed 26638186
N Funayama, Y Sato, K Matsumoto, T Ogura, Y Takahashi Coelom formation: binary decision of the lateral plate mesoderm is controlled by the ectoderm. Development: 1999, 126(18);4129-38 PubMed 10457021
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|Embryology History | Historic Embryology Papers)|
- atresia- obstruction.
- eppiglottis- develops from hypobrachial eminence.
- fistula- abnormal comunication.
- hypopharyngeal eminence- fusion of 3rd pharyngeal arches, precursor of root of tongue.
- laryngotracheal groove- forms on anterior (ventral) wall of pharynx, gives rise to larynx, trachea, respiratory tree.
- larynx- lining from endoderm, cartilage from pharyngeal arch 4 and 6.
- lung buds- primordia of lungs.
- parietal pleura-outer lining of pleural cavity derived from epithelia of pericardioperitoneal canals from intra-embryonic coelom.
- pleural cavity- walls derived from pericardioperitoneal canals -> intra-embryonic coelom ->coelomic spaces -> lateral mesoderm -> mesoderm.
- pleuropericardial fold- restricts the communication between pleural cavity and pericardiac cavity, contains cardinal vein and phrenic nerve.
- pleuroperitoneal membrane- forms inferiorly at transverse septum to separate peritoneum from pleural cavity.
- septum transversum- mesoderm separating thoracic cavity and yolk sac, forms central tendon of diaphragm (and some of liver?).
- stenosis- narrowing
- surfactant- a detergent secreted by Type 2 alveolar cells between alveolar epithelium. Functions to lower surface tension, allowing lungs to remain inflated.
- visceral pleura- inner lining of pleural cavity derived from contact epithelia with lung bud of pericardioperitoneal canals from intra-embryonic coelom.
|System Links: Introduction | Cardiovascular | Coelomic Cavity | Endocrine | Gastrointestinal Tract | Genital | Head | Immune | Integumentary | Musculoskeletal | Neural | Neural Crest | Placenta | Renal | Respiratory | Sensory | Birth|
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Cite this page: Hill, M.A. 2017 Embryology Coelomic Cavity Development. Retrieved July 22, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Coelomic_Cavity_Development
- © Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G