Bilaminar embryo

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Introduction

The "two layered" embryo, used to describe the inner cell mass differentiating to form an initial two layered structure (epiblast and hypoblast). In human development, this occurs during the second week (GA week 4). The epiblast layer will then form the majority of the embryo.

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Some Recent Findings

  • Self-organization of the human embryo in the absence of maternal tissues[1] "Remodelling of the human embryo at implantation is indispensable for successful pregnancy. Yet it has remained mysterious because of the experimental hurdles that beset the study of this developmental phase. Here, we establish an in vitro system to culture human embryos through implantation stages in the absence of maternal tissues and reveal the key events of early human morphogenesis. These include segregation of the pluripotent embryonic and extra-embryonic lineages, and morphogenetic rearrangements leading to generation of a bilaminar disc, formation of a pro-amniotic cavity within the embryonic lineage, appearance of the prospective yolk sac, and trophoblast differentiation. Using human embryos and human pluripotent stem cells, we show that the reorganization of the embryonic lineage is mediated by cellular polarization leading to cavity formation. Together, our results indicate that the critical remodelling events at this stage of human development are embryo-autonomous, highlighting the remarkable and unanticipated self-organizing properties of human embryos."
More recent papers  
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Search term: Bilaminar Embryo

<pubmed limit=5>Bilaminar embryo</pubmed>

Search term: Epiblast

<pubmed limit=5>Epiblast</pubmed>

Search term: Hypoblast

<pubmed limit=5>Hypoblast</pubmed>

References

  1. <pubmed>PMID27144686</pubmed>

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June 2010 "bilaminar embryo" All (67) Review (5) Free Full Text (11)


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Cite this page: Hill, M.A. (2019, March 24) Embryology Bilaminar embryo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Bilaminar_embryo

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G