2010 BGD Practical 3 - Notochord
The embryonic structure which establishes body axes and patterns surrounding tissues is called the notochord.
The notochord is a midline column of cells running in a rostrocaudal direction (head-tail) within the mesoderm layer. It exists as a transient developmental patterning structure with a role in molecular signaling (patterning) and controlling the direction of embryonic disc folding (mechanical). These images are of the embryonic disc in week 3 (stage 7).
The notochordal process begins as a fold of ectoderm extending cranially toward the prechordal plate region. The sequence of differentiation: notochordal process -> notochordal plate -> notochord.
- Elongation of the notochordal process cranially from the primitive pit as a hollow tube (notochordal canal) in the midline of the embryonic disc underlying the ectoderm.
- The notochordal canal may appear to break down on the endodermal side forming a notochordal plate continuous with the endodermal layer.
- Notochordal plate folds to form notochord. The notochord (also called axial mesoderm) is an embryonic structure that regulates differentiation of surrounding structures including the overlying ectoderm (neural plate) and mesoderm (somites).
Folding: all edges of the embryonic disc will fold ventrally, forming a rostro-caudal "C" shaped tube.
|Chorionic Cavity||Amniotic Cavity||Week 3|
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Cite this page: Hill, M.A. (2019, September 20) Embryology 2010 BGD Practical 3 - Notochord. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2010_BGD_Practical_3_-_Notochord
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G