User talk:Z3439257: Difference between revisions
From Embryology
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PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1. | PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1. | ||
=== | ===Embryological events based on animal models=== | ||
====Chicken==== | |||
====Human==== | |||
====Mouse==== | |||
====Xenopus==== | |||
===Animal Models=== | ===Animal Models=== | ||
Revision as of 15:05, 10 October 2016
Wnt calcium ion signalling pathway
General introduction
- Ligands: Wnt-4, -5a & -11
- Downstream targets: CAMKII, calcineurin & PKC
- Main functions:
- Regulation of cell adhesion, migration and tissue separation (mediated by CAMKII)
- Inhibition of TCF/Beta-catenin signalling (mediated by calcineurin)
- Ventral patterning (mediated by PKC)
Molecular Basis
Wnt-4, -5a & -11 were identified as ligands specifically activate this pathway. Wnt (5a) interact with Fz receptor. Fz receptor functions as a G-protein coupled receptor which activates Gaq/11. Gaq/11 further cleaves PIP2 into DAG and IP3. IP3 then interacts with the IP3R on the surface of endoplasmic reticulum and causes increase in intracellular calcium ions. Those calcium ions will then react with CAMKII or calcineurin leading to further internal effects. DAG and calcium ions are also able to activate proteins belongs to PKC family which also posses various cellular effects.
PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1.
Embryological events based on animal models
Chicken
Human
Mouse
Xenopus
Animal Models
Xenopus Mouse Chicken Human
