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ILP2015 - Is there a role for Natural Killer cells in ectopic pregnancy? | ILP2015 - Is there a role for Natural Killer cells in ectopic pregnancy? | ||
===Uterine NK cells: active regulators at the maternal-fetal interface=== | |||
J Clin Invest. 2014 May;124(5):1872-9. doi: 10.1172/JCI68107. Epub 2014 May 1. | |||
Moffett A, Colucci F. | |||
Abstract | |||
Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably physiological. Indeed, genetic epidemiological data suggest that the variability of NK cell receptors and their MHC ligands define pregnancy success; however, exactly how uNK cells function in normal and pathological pregnancy is still unclear, and any therapies aimed at suppressing NK cells must be viewed with caution. Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation. | |||
PMID 24789879 | |||
Revision as of 13:09, 23 April 2015
ILP2015 - Is there a role for Natural Killer cells in ectopic pregnancy?
Uterine NK cells: active regulators at the maternal-fetal interface
J Clin Invest. 2014 May;124(5):1872-9. doi: 10.1172/JCI68107. Epub 2014 May 1.
Moffett A, Colucci F.
Abstract
Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably physiological. Indeed, genetic epidemiological data suggest that the variability of NK cell receptors and their MHC ligands define pregnancy success; however, exactly how uNK cells function in normal and pathological pregnancy is still unclear, and any therapies aimed at suppressing NK cells must be viewed with caution. Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.
PMID 24789879
