User:Z3332824

IVF Homework Questions - Lab 1 Assessment

1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.

Louise Brown was the first successful IVF baby, born in 1978 in Britain. Research into this area had been progressing for at least twenty years prior to this time, and still continues today. In 2010, the Nobel Prize in Physiology or Medicine was awarded to Robert Edwards for his development and contribution to IVF therapy.

2. Identify a recent paper on fertilisation and describe its key findings.

A new technique that has been developed is the screening of sperm using fluorescents. This enables the doctor to study the sperm's health and chromosomes, and can detect genetic abnormalities and chromosome aneuploidy. It has been extremely useful as an aid for couples whoare having difficulty conceiving, especially in cases of couples who have had multiple IVF attempts.

Link: http://www.ncbi.nlm.nih.gov/pubmed/21789092

3. Identify 2 congenital anomalies.

-Spina bifida

-Cystic fibrosis

--User:Z3332824 15:44, 29 July 2011 (EST)

--Mark Hill 00:48, 30 July 2011 (EST) Well done. the reference link is good or you could have: The use of fluorescent in situ hybridization in male infertility. Hwang K, Weedin JW, Lamb DJ. Ther Adv Urol. 2010 Aug;2(4):157-69. PMID: 21789092

or

A new technique that has been developed is the screening of sperm using fluorescents. This enables the doctor to study the sperm's health and chromosomes, and can detect genetic abnormalities and chromosome aneuploidy. It has been extremely useful as an aid for couples whoare having difficulty conceiving, especially in cases of couples who have had multiple IVF attempts.

References

ZP3 Glycoprotein Lab 2 Assessment

1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.

Sperm possess a special protein on their heads that upon reaching the egg in the female, interact with glycoprotein ZP3, a sperm receptor molecule on the zona pellucida. This receptor is species-specific – i.e. only a human sperm can fuse with a human egg. ZP3 induces degradative enzymes stored in the sperm’s acrosome to be released, enabling the sperm to break through the tough zona pellucida and reach the oocyte.

--User:Z3332824 22:15, 5 August 2011 (EST)

Maternal Diet During Pregnancy - Lab 3 Assessment

A women's diet is extremely important when she is pregnant, and she must be careful to keep up the proper nutrition needed for her baby. An example is folate, as it helps prevent spina bificda. In addition to folate, iodine is also very important in the growth and development of the baby's neural development. Iodine is necessary for normal thyroid function - this is an important endocrine organ, especially in babies and young children. The thyroid gland produces hormones that are vital for nervous system and brain development.

--User:Z3332824 17:56, 17 August 2011 (EST)