User:Z3332824

Lab Attendance

Lab 1 Attendance:

--Z3332824 12:52, 28 July 2011 (EST)

Lab 2 Attendance:

--Z3332824 11:17, 4 August 2011 (EST)

Lab 3 Attendance:

--Z3332824 12:36, 11 August 2011 (EST)

Lab 5 Attendance:

--Rhiannon Bice 10:38, 25 August 2011 (EST)

IVF Homework Questions - Lab 1 Assessment

1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.

Louise Brown was the first successful IVF baby, born in 1978 in Britain. Research into this area had been progressing for at least twenty years prior to this time, and still continues today. In 2010, the Nobel Prize in Physiology or Medicine was awarded to Robert Edwards for his development and contribution to IVF therapy.

2. Identify a recent paper on fertilisation and describe its key findings.

A new technique that has been developed is the screening of sperm using fluorescents. This enables the doctor to study the sperm's health and chromosomes, and can detect genetic abnormalities and chromosome aneuploidy. It has been extremely useful as an aid for couples whoare having difficulty conceiving, especially in cases of couples who have had multiple IVF attempts.

Link: http://www.ncbi.nlm.nih.gov/pubmed/21789092

3. Identify 2 congenital anomalies.

-Spina bifida

-Cystic fibrosis

--User:Z3332824 15:44, 29 July 2011 (EST)

--Mark Hill 00:48, 30 July 2011 (EST) Well done. the reference link is good or you could have: The use of fluorescent in situ hybridization in male infertility. Hwang K, Weedin JW, Lamb DJ. Ther Adv Urol. 2010 Aug;2(4):157-69. PMID: 21789092

or

A new technique that has been developed is the screening of sperm using fluorescents. This enables the doctor to study the sperm's health and chromosomes, and can detect genetic abnormalities and chromosome aneuploidy. It has been extremely useful as an aid for couples whoare having difficulty conceiving, especially in cases of couples who have had multiple IVF attempts.

References

ZP3 Glycoprotein Lab 2 Assessment

1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.

Sperm possess a special protein on their heads that upon reaching the egg in the female, interact with glycoprotein ZP3, a sperm receptor molecule on the zona pellucida. This receptor is species-specific – i.e. only a human sperm can fuse with a human egg. ZP3 induces degradative enzymes stored in the sperm’s acrosome to be released, enabling the sperm to break through the tough zona pellucida and reach the oocyte.

--User:Z3332824 22:15, 5 August 2011 (EST)

Maternal Diet During Pregnancy - Lab 3 Assessment

1. What is the maternal dietary requirement for late neural development?

A women's diet is extremely important when she is pregnant, and she must be careful to keep up the proper nutrition needed for her baby. An example is folate, as it helps prevent spina bificda. In addition to folate, iodine is also very important in the growth and development of the baby's neural development. Iodine is necessary for normal thyroid function - this is an important endocrine organ, especially in babies and young children. The thyroid gland produces hormones that are vital for nervous system and brain development.

2. Upload a picture relating to your group project

Patterns of zona pellucida deposition and ZPC-ubiquitin colocalization in porcine ocyte-cumulus complexes isolated from small antral follicles.

References

--User:Z3332824 17:56, 17 August 2011 (EST)

Lab 4 Online Assessment

1. The allantois, identified in the placental cord, is continuous with what anatomical structure? The allantois is a thin extension of the cloaca and extends into the connecting stalk and yolk sac. Later in development it becomes part of the bladder in the urogenital sinus.

2. Identify the 3 vascular shunts, and their location, in the embryonic circulation. -The first shunt is in the heart, and is called the foramen ovale. It allows direct blood flow between the atria of the embryo.

-The second is the ductus arteriosis connecting the descending aortic arch to the pulmonary artery.

-The third shunt is the ductus venosus and connects the portal sinus with the inferior vena cava.

--User:z3332824 10:37, 25 August 2011 (EST)