User:Z3290558

Lab 4 Online Assessment

The allantois, identified in the placental cord, is continuous with what anatomical structure?
Identify the 3 vascular shunts, and their location, in the embryonic circulation.
Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)

Lab Assessment 2

1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.

During fertilization, the ZP protein in which spermatozoa specifically binds to is the ZP3 glycoprotein. After fertilization, a ‘zona reaction’ occurs which is the process where the properties of the ZP is changed, making it impermeable to other sperms. This happens near the plasma membrane of the oocyte where the cortical granules release lysosomal enzymes into the perivitelline space which causes changes to the plasma membrane, making it impermeable to other sperms.

2. Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page)

Group 4 Topic: Neural Tube Defect

Research Article:

Conway S.J., Gosnell M., Rogers R., Simmons O., Snider P., Young R. (2011), Notochordal and foregut abnormalities correlate with elevated neural crest apoptosis in Patch embryos. Birth Defects Research Part A: Clinical and Molecular Teratology. doi: 10.1002/bdra.20802. Epub 2011 May 6.

http://www.ncbi.nlm.nih.gov/pubmed/21557455

Review Article:

Abdel-Hamed Z., Johnson C.A., Logan C.V. (2011), Molecular genetics and pathogenic mechanisms for the severe ciliopathies: insights into neurodevelopment and pathogenesis of neural tube defects. Molecular Neurobiology

http://www.ncbi.nlm.nih.gov/pubmed/21110233

--z3290558 02:04, 11 August 2011 (EST)

Lab Assessment 1

1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.

- Origin: The research for IVF dates back from the US from the 1930's where experiments were carried out in rabbits. Human IVF was first attempted in the 1940's by John Rock where he used 138 human oocytes and was the first to extract an intact fertilised egg. The first attempt at a human IVF pregnancy was attempted in 1973 by a team from Monash University which only lasted a few days, being unsuccessful. However soon after in 1977, the first successful pregnancy was achieved by Patrick Steptoe and Robert Edwards, resulting in the birth of Louise Brown on 25 July 1978.

- 2010 Nobel Prize winner for the development of IVF: Dr. Robert G. Edwards

2. Identify a recent paper on fertilisation and describe its key findings.

"Pregnancy after Age 50: Defining Risks for Mother and Child." Kort DH, Gosselin J, Choi JM, Thornton MH, Cleary-Goldman J, Sauer MV. Source Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.

Key Findings: This paper found that by using donor-egg in vitro fertilisation, women in their 50's were able to achieve a successful pregnancy. This involved high risks regarding maternal complications such as cesarean and hypertensive disorders in the 50 year old women, however this level of risk was found to be at a similar rate to the younger recipients.

3. Identify 2 congenital anomalies.

Cleft Palate

Spina Bifida

Attendance

--Lisa Lee 12:16, 11 August 2011 (EST)

--Z3290558 12:56, 28 July 2011 (EST)

--z3290558 12:53, 4 August 2011 (EST)

--Mark Hill 09:53, 3 August 2011 (EST) You need to have answers to these 3 questions before Lab 2.