User:Z3289066
Lab 4 Online Assessment
- The allantois, identified in the placental cord, is continuous with what anatomical structure?
- Identify the 3 vascular shunts, and their location, in the embryonic circulation.
- Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)
Lab Attendance
--Z3289066 12:21, 28 July 2011 (EST)
--z3289066 12:53, 4 August 2011 (EST)
--z3289066 11:09, 11 August 2011 (EST)
--Elisabeth Karsten 11:28, 18 August 2011 (EST)
Labs
Lab One
Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.
The first incidence of in vitro fertilization was in 1978 by Edwards RG. et al. who then received the nobel prize for his work in 2010. Since then, work in in vitro fertilisation has extended into Assisted Reproductive Technologies (ART) which now incorporates 17 different techniques.
Identify a recent paper on fertilisation and describe its key findings.
This paper refers to research concerning sperm chemotoxis and it's 'journey' to the oocyte and consequential fertilisation. It describes the selective process involved in fertilisation and the potential of the involvement of fluid shear in this selection.[1]
Identify 2 congenital anomalies.
- Dandy–Walker syndrome - This is a congential brain malformation which is associated with the partial or complete absence of part of the brain, often involving the cerebellum.
- Amniotic band syndrome - This involves the constriction of the limbs by the amniotic band potentially resulting in swelling of limbs, constriction or amputation.
Lab Two
Identify the zona pellucida protein that spermatozoa binds and how is this changed (altered) after fertilization.
The sperm binds to the receptor Zona Pellucida Protein 3 (ZP3) on the zona pellucida which is surrounding the oocyte. This is necessary for entry into the oocyte, and thus fertilisation. After fertilisation, the membrane is depolarised as a primary block to polyspermy. The IP3 pathway is activated, leading to an increase in intraceullar calcium and altering ZP3, so that it will no longer binds sperm to the membrane and acting as another block to polyspermy.
Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page)
Lab Three
What is the maternal dietary requirement for late neural development?
Folate is essential for late neural development. Its use has been associated with a decrease in neural tube defects. These defects include spina bifida which results from a lack of neural tube closure, or anencephaly which is the result of a lack of cranial neural tube closure.
Upload a picture relating to you group project.
Lab Four
The allantois, identified in the placental cord, is continuous with what anatomical structure?
The allantois is continuous with the hind gut (and endoderm) of the embryo.
Identify the 3 vascular shunts, and their location, in the embryonic circulation.
- Ductus venosus - this is situated between the umbilical view and inferior vena cava
- Ductus arteriosus - this is situated between the pulmonary artery and the descending aorta
- Foramen ovale - this is situated between the right and left artium
Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)
- Treatment/Management
- Current Research
References
--Mark Hill 00:40, 30 July 2011 (EST) Well done, you do remember some of cell biology online work. Since you have completed this online work before, perhaps you will also be able to help the students new to this format.
