Trigone Development Movie

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Development of the Trigone Region of the Urinary Bladder
Trigone 001 icon.jpg

The dorsal bladder region bounded by the 2 ureters and the urethra form the region known as the trigone. The classical embryology description of the origin of this region was from the mesonephric duct (Wolffian duct), as shown in this animation. The current understanding is that the region is entirely endoderm in origin.

More recent mouse studies suggest that this bladder region is endodermal and not mesodermal in origin.[1] Using a similar mouse model, this trigone embryonic region appears to contain most of the bladder progenitor cells.[2] Any mesonephric duct (Wolffian duct) located in the mouse trigone region appears to be developmentally lost by apoptosis.[3]

In contrast, the prostatic central zone, seminal vesicle, and ejaculatory ducts all originate from the mesonephric duct (Wolffian duct).[4]

  • This simple animation shows early renal system development associated with the urinary bladder.
  • dorsal view (from behind) showing the mesonephric ducts initially attached to the bladder


Trigone Links: MP4 movie | Bladder Development | Renal Development
  1. Tanaka ST, Ishii K, Demarco RT, Pope JC, Brock JW & Hayward SW. (2010). Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interaction. J. Urol. , 183, 386-91. PMID: 19914648 DOI.
  2. Sun W, Wilhelmina Aalders T & Oosterwijk E. (2014). Identification of potential bladder progenitor cells in the trigone. Dev. Biol. , 393, 84-92. PMID: 24992712 DOI.
  3. Mendelsohn C. (2009). Using mouse models to understand normal and abnormal urogenital tract development. Organogenesis , 5, 306-14. PMID: 19568352
  4. Quick CM, Gokden N, Sangoi AR, Brooks JD & McKenney JK. (2010). The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis. Hum. Pathol. , 41, 1145-9. PMID: 20413145 DOI.


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Cite this page: Hill, M.A. (2019, August 22) Embryology Trigone Development Movie. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Trigone_Development_Movie

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G