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Latest revision as of 16:10, 8 September 2023

News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells

Carnegie Stage 6 Embryo

This recent Nature paper^[1] describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.

"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."

Links: stem cells | Carnegie stage 6

↑ Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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[PMID37673118-1] Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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-| <span style="font-size:150%">'''News - Embryonic Development - Kyoto eBook</span>
+| <span style="font-size:150%">'''News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells'''</span>
 |-bgcolor="F5FAFF"
-| valign=top| [[File:Kyoto Embryo Collection - cover.jpg|200px|left|alt=Kyoto Embryo Collection|link=http://itunes.apple.com/us/book/id1143922693]]
+| valign=top|[[File:Stage6 bf03.jpg|thumb|150px|alt=Carnegie Stage 6 Embryo|Carnegie Stage 6 Embryo]]
-[[File:AvailableBook.png|150px|right|link=https://itunes.apple.com/au/book/kyoto-embryo-collection/id1143922693?mt=11]]
-The Kyoto embryo collection is the largest collection of human embryos in the world, it therefore provides a unique research and educational resource for studying all aspects of early human development.
-This iBook now allows you to observe selected embryos from the first 8 weeks after fertilization and explore for yourself the changes that occur in normal human development during this key period. This atlas of the Kyoto embryos from Carnegie Stage 7 to 23 provides a brief description of each stage, surface views, interactive images, histology, movies and a glossary.
+This recent Nature paper{{#pmid:37673118|PMID37673118}} describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.
+"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."
-:'''Links:''' [[Kyoto Collection]] | [[Embryology iBooks]]
+:'''Links:''' {{stem cells}} | Carnegie stage {{CS6}}
+<references/>
+{| class="wikitable mw-collapsible mw-collapsed"
+! Older News Articles &nbsp;
 |-
-|
+| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#January|Climate Change Abnormal Development]] | [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]]
-:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#November|Maternal Diabetes]] | [[Template_talk:Main_Page_News#September|Zika]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]]  | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]]
+|}
 |}