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Latest revision as of 16:10, 8 September 2023

News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells

Carnegie Stage 6 Embryo

This recent Nature paper^[1] describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.

"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."

Links: stem cells | Carnegie stage 6

↑ Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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[PMID37673118-1] Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

[1]

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-{| width=700px|
+{| width=800px|
 |-bgcolor="CEDFF2"
-| <span style="font-size:150%">'''News - Ronan O’Rahilly, Anatomist and Embryologist, Dies at 96'''</span>
+| <span style="font-size:150%">'''News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells'''</span>
 |-bgcolor="F5FAFF"
-| valign=top|[[File:Ronan O'Rahilly 1987.jpg|thumb|alt=Ronan O'Rahilly 1987|link=Embryology_History_-_Ronan_O%27Rahilly#Obituary|Ronan O'Rahilly (1987 Carnegie Labs)]]
+| valign=top|[[File:Stage6 bf03.jpg|thumb|150px|alt=Carnegie Stage 6 Embryo|Carnegie Stage 6 Embryo]]
-[[Embryology History - Ronan O'Rahilly|'''Ronan O'Rahilly''']] (June 24, 2018) Professor, School of Medicine, University of California, Davis, CA, USA.
-[[Embryology_History_-_Ronan_O%27Rahilly#Obituary|Obituary excerpt]]
+This recent Nature paper{{#pmid:37673118|PMID37673118}} describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.
-:"Ronan O’Rahilly, MD, human anatomist and embryologist, scholar, scientist, and academic whose research produced insights into our understanding of the developing human at all stages, died on June 24, 2018 in Villars-sur-Glâne, Switzerland. He was 96 and had formerly lived in Ireland, England, the United States and most recently in Fribourg, Switzerland."
-Search Pubmed - [http://www.ncbi.nlm.nih.gov/pubmed/?term=O'Rahilly+R%5BAuthor%5D O'Rahilly R]
+"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."
-<br><br>
+:'''Links:''' {{stem cells}} | Carnegie stage {{CS6}}
-:[[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#February|Gestational Diabetes]] | [[Template_talk:Main_Page_News#September|Kyoto eBook]] | [[Template_talk:Main_Page_News#August|Dolly's sisters live on!]] | [[Template_talk:Main_Page_News#June|Thalidomide in Zebrafish]]  | [[Template_talk:Main_Page_News#March|Human pancreas stem cells]] | [[Template_talk:Main_Page_News#January|Oral contraceptive no risk of major birth defects]] | [[Template_talk:Main_Page_News#September|Maternal Malaria Neurovascular Development Effects]] | [[Template_talk:Main_Page_News#June|Oocyte/Spermatozoa fate decision]] [[Template_talk:Main_Page_News#April|Rubella eliminated in the Americas]] | [[Template_talk:Main_Page_News#February|Three-person embryos]]
+<references/>
+{| class="wikitable mw-collapsible mw-collapsed"
+! Older News Articles &nbsp;
+|-
+| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#January|Climate Change Abnormal Development]] | [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]]
+|}
 |}