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Latest revision as of 16:10, 8 September 2023

News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells

Carnegie Stage 6 Embryo

This recent Nature paper^[1] describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.

"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."

Links: stem cells | Carnegie stage 6

↑ Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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[PMID37673118-1] Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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-| colspan=2|<span style="font-size:150%">'''Three-person embryos'''</span>
+| <span style="font-size:150%">'''News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells'''</span>
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+| valign=top|[[File:Stage6 bf03.jpg|thumb|150px|alt=Carnegie Stage 6 Embryo|Carnegie Stage 6 Embryo]]
-[[File:Mitochondria EM01.jpg|250px|left]]
-| '''2014 Nobel Prize in Physiology or Medicine'''
+This recent Nature paper{{#pmid:37673118|PMID37673118}} describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.
-John O´Keefe, May-Britt Moser and Edvard I. Moser - ''for their discoveries of cells that constitute a positioning system in the brain''
+"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."
-:(More?
-[[Template_talk:Main_Page_News|Older News Articles]]
+:'''Links:''' {{stem cells}} | Carnegie stage {{CS6}}
-*  2014 Nobel Prize in Physiology or Medicine -  [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2014/press.html Nobel Press Release] | [[Neural_-_Hippocampus_Development|Hippocampus Development]]
-* Embryo Epigenetics - after fertilisation human embryos loose DNA methylation from most of the genome.
+<references/>
-* WHO - Trends in Maternal Mortality 1990 to 2013. [[Statistics - Maternal Mortality]] | [http://www.who.int/reproductivehealth/publications/monitoring/maternal-mortality-2013/en WHO Report Page]
+{| class="wikitable mw-collapsible mw-collapsed"
-* WHO - polio has re-emerged as a public health emergency.  [[Abnormal Development - Polio Virus|Polio Virus]]
+! Older News Articles &nbsp;
-* Trisomy 21 [[Template_talk:Main_Page_News#March|Genome-wide Effects]]
+|-
-* RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers  [http://www.riken.jp/en/pr/press/2014/20140401_2/RIKEN press release April 1, 2014] | [http://news.sciencemag.org/asiapacific/2014/04/riken-panel-finds-misconduct-reprogrammed-stem-cell-papers Science April 2014]
+| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#January|Climate Change Abnormal Development]] | [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]]
-|}<noinclude>[[Category:Template]][[Category:2014]]</noinclude>
+|}
+|}