Template:Anderson2016 collapsetable2

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Table 2. Summary of Timing (Post Fertilization) of Cardiac Susceptibility to a Drug-Induced Malformation  
Lesion Start of Susceptibility
to Malformation
End of Susceptibility
to Malformation
Interatrial communications
Oval fossa defect 6 weeks (E13.5) Term
Sinus venosus defect 8 weeks 12 weeks
Coronary sinus defect 8 weeks Term
Vestibular defect 7 weeks 8 weeks
Ventricular Septal Defect
Muscular 8 weeks Difficult to predict
Perimembranous 6 weeks 8 weeks
Doubly committed 7 weeks 8 weeks
Atrioventricular Septal Defect
Ostium primum 5 weeks 6 weeks
“Complete” 5 weeks 6 weeks
Aortic coarctation
With VSD 5 weeks 8 weeks
With intact ventricular septum 8 weeks Term
Double Outlet Right Ventricle 6 weeks 8 weeks
Transposition of Great Arteries 6 weeks 8 weeks
Ebstein’s malformation 6 weeks 8 weeks
Hypoplastic left heart syndrome
With mitral atresia 5 weeks 8 weeks
With mitral stenosis 8 weeks Term
Pulmonary atresia
With VSD 6 weeks 8 weeks
With intact ventricular septum 8 weeks Term
Other
Functionally single ventricle 5 weeks 6 weeks
Tetralogy of Fallot 7 weeks 8 weeks
Totally anomalous pulmonary venous return 8 weeks 12 weeks
Tricuspid atresia 5 weeks 6 weeks
Common arterial trunk 5 weeks 7 weeks
Bicuspid aortic valve 6 weeks Term

Notes: For approximate clinical Gestational Age GA add 2 weeks; number in brackets is mouse equivalent.

Reference: Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)