Template:Anderson2016 collapsetable2: Difference between revisions
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Revision as of 11:50, 16 February 2017
Table 2. Summary of Timing (Post Fertilization) of Cardiac Susceptibility to a Drug-Induced Malformation | ||
---|---|---|
Lesion | Start of Susceptibility to Malformation |
End of Susceptibility to Malformation |
Interatrial communications | 6 weeks (E13.5) | Term |
Oval fossa defect | 8 weeks | 12 weeks |
Sinus venosus defect | 8 weeks | Term |
Coronary sinus defect | 7 weeks | 8 weeks |
Vestibular defect | ||
Ventricular Septal Defect | ||
Muscular | 8 weeks | Difficult to predict |
Perimembranous | 6 weeks | 8 weeks |
Doubly committed | 7 weeks | 8 weeks |
Atrioventricular Septal Defect | ||
Ostium primum | 5 weeks | 6 weeks |
“Complete” | 5 weeks | 6 weeks |
Aortic coarctation | ||
With VSD | 5 weeks | 8 weeks |
With intact ventricular septum | 8 weeks | Term |
Double Outlet Right Ventricle | 6 weeks | 8 weeks |
Transposition of Great Arteries | 6 weeks | 8 weeks |
Ebstein’s malformation | 6 weeks | 8 weeks |
Hypoplastic left heart syndrome | ||
With mitral atresia | 5 weeks | 8 weeks |
With mitral stenosis | 8 weeks | Term |
Pulmonary atresia | ||
With VSD | 6 weeks | 8 weeks |
With intact ventricular septum | 8 weeks | Term |
Other | ||
Functionally single ventricle | 5 weeks | 6 weeks |
Tetralogy of Fallot | 7 weeks | 8 weeks |
Totally anomalous pulmonary venous return | 8 weeks | 12 weeks |
Tricuspid atresia | 5 weeks | 6 weeks |
Common arterial trunk | 5 weeks | 7 weeks |
Bicuspid aortic valve | 6 weeks | Term |
Notes | ||
For approximate clinical Gestational Age GA add 2 weeks; number in brackets is mouse equivalent.
Reference: Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016) |