Talk:Z3186093

http://www.fao.org/docrep/t1690E/t1690e06.htm#TopOfPage

Nucleotide sequencing: http://www.ncbi.nlm.nih.gov/nuccore/256946799

• Too many nucleotides to list (9986)
• 3 papers to look at
• 84024 rc by 31-AUG-2009
• Sequence has been completed twice by Initial Shotgun Sequence and assembly. Currently there are another 7 groups to recomplete this.

Embryological development is after all the opportunity for a specific Genome to be expressed, regulated and utilized as it will never be again in the adult animal.

Assessment Criteria:

Procedure

   * Project initial assessment by other groups after the Group Project submission date.
         o Written comments will be added to the discussion page. 
   * Group will have opportunity to work on the project in response to comments.
         o Individuals will provide an assessment of their contribution to the final project on their own student page. 
   * Final assessment by course co-ordinator. 20% of final course assessment mark 

Content

Does the group project include the following information?

   * Timeline of Development (how long and key events)
   * Staging (is there a species specific staging and what criteria are used)
   * History of Model Use (what embryological studies have used this model)
   * Genetics (chromosome number, genome sequencing)
   * Current Embryology Research (what embryological studies have used this model) 

Structure

   * Are there visual ways of representing information?
   * Is the content correctly referenced in a reference list?
   * Are there links to related resources/research laboratories? 

Contribution

   * Have all group members contributed?
   * Has the group responded to peer assessment feedback?

RABBIT GENOME: The National Human Genome Research Institute selected the European rabbit (Oryctolagus cuniculus) for whole genome sequencing to enhance their understanding of the human genome and use it experimentally for an animal model for human disease. (1)

The European rabbit (Oryctolagus cuniculus) has been sequenced twice by The Broad Institute as part of the mammalian genome project. It is now currently undergoing 7 more sequencing projects. Its sequencing is made by the Shotgun Sequence and assembly method. This is when genomic DNA is sheared into small pieces of approximately 2000 base pairs which are then cloned into plasmids and sequenced on both strands. Once the millions of sequenced fragments are read, realigned and reassembled by computer algorithms it will give the overall sequence. (2) (3)

Rabbit Genome from the Nucleotide Data Bank

References

1. National Center for Biotechnology Information. (June 16, 2009). Rabbit Genome Resources, Retrieved August 20, 2009, from NCBI Rabbit Genome Site
2. Campbell, M. A. (2002). Sequencing Whole Genomes: Hierarchical Shotgun Sequencing v. Shotgun Sequencing Retrieved August 31, 2009, from Shotgun Sequencing - 1
3. Trivedi, B. (2000). Sequencing the Genome. Retrieved September 4, 2009, from Shotgun Sequencing - 2
4. The Broad Institute. (2008). Rabbit Genome Sequencing Project. Retrieved only August 29, 2009, from Rabbit Genome Sequencing Project