Talk:Neural - Prosencephalon Development

2009

The role of Robo3 in the development of cortical interneurons

Barber M, Di Meglio T, Andrews WD, Hernández-Miranda LR, Murakami F, Chédotal A, Parnavelas JG. Cereb Cortex. 2009 Jul;19 Suppl 1:i22-31. Epub 2009 Apr 14.

A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we investigated the expression and function of Robo3 in the developing cortex. We found that this receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal-Retzius cells and interneurons. Analysis of Robo3 mutant mice at early (embryonic day [E] 13.5) and late (E18.5) stages of corticogenesis revealed no significant change in the number of interneurons, but a change in their morphology at E13.5. However, preliminary analysis on a small number of mice that lacked all 3 Robo receptors indicated a marked reduction in the number of cortical interneurons, but only a limited effect on their morphology. These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons.

PMID: 19366869 http://www.ncbi.nlm.nih.gov/pubmed/19366869

Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling

Snapyan M, Lemasson M, Brill MS, Blais M, Massouh M, Ninkovic J, Gravel C, Berthod F, Götz M, Barker PA, Parent A, Saghatelyan A. J Neurosci. 2009 Apr 1;29(13):4172-88. PMID: 19339612

Adult neuronal precursors retain the remarkable capacity to migrate long distances from the posterior (subventricular zone) to the most anterior [olfactory bulb (OB)] parts of the brain. The knowledge about the mechanisms that keep neuronal precursors in the migratory stream and organize this long-distance migration is incomplete. Here we show that blood vessels precisely outline the migratory stream for new neurons in the adult mammalian forebrain. Real-time video imaging of cell migration in the acute slices demonstrate that neuronal precursors are retained in the migratory stream and guided into the OB by blood vessels that serve as a physical substrate for migrating neuroblasts. Our data suggest that endothelial cells of blood vessels synthesize brain-derived neurotrophic factor (BDNF) that fosters neuronal migration via p75NTR expressed on neuroblasts. Interestingly, GABA released from neuroblasts induces Ca(2+)-dependent insertion of high-affinity TrkB receptors on the plasma membrane of astrocytes that trap extracellular BDNF. We hypothesize that this renders BDNF unavailable for p75NTR-expressing migrating cells and leads to their entrance into the stationary period. Our findings provide new insights into the functional organization of substrates that facilitate the long-distance journey of adult neuronal precursors.

2007

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

Zaghetto AA, Paina S, Mantero S, Platonova N, Peretto P, Bovetti S, Puche A, Piccolo S, Merlo GR. J Neurosci. 2007 Sep 5;27(36):9757-68. PMID: 17804636 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text

Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain

Kudo LC, Karsten SL, Chen J, Levitt P, Geschwind DH. Cereb Cortex. 2007 Sep;17(9):2108-22. Epub 2006 Dec 5. PMID: 17150988

Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain

Zhang Y, Chen YT, Xie S, Wang L, Lee YF, Chang SS, Chang C. Mol Endocrinol. 2007 Apr;21(4):908-20. Epub 2007 Jan 16. PMID: 17227886

2006

MEKK4 signaling regulates filamin expression and neuronal migration

Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P. Neuron. 2006 Dec 7;52(5):789-801. PMID: 17145501 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text

Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins

Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. J Neurosci. 2006 Jul 19;26(29):7756-66. PMID: 16855103

Organization and evolution of the avian forebrain

Reiner A, Yamamoto K, Karten HJ. Anat Rec A Discov Mol Cell Evol Biol. 2005 Nov;287(1):1080-102. Review. PMID: 16206213

Retinoic acid signaling identifies a distinct precursor population in the developing and adult forebrain

Haskell GT, LaMantia AS. J Neurosci. 2005 Aug 17;25(33):7636-47. PMID: 16107650

In vivo imaging of migrating neurons in the mammalian forebrain

Davenne M, Custody C, Charneau P, Lledo PM. Chem Senses. 2005 Jan;30 Suppl 1:i115-6. No abstract available. PMID: 15738066

Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry

Peng J, Kim MJ, Cheng D, Duong DM, Gygi SP, Sheng M. J Biol Chem. 2004 May 14;279(20):21003-11. Epub 2004 Mar 12. PMID: 15020595

2003

Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development

Walshe J, Mason I. Development. 2003 Sep;130(18):4337-49. PMID: 12900450

The trophic role of oligodendrocytes in the basal forebrain

Dai X, Lercher LD, Clinton PM, Du Y, Livingston DL, Vieira C, Yang L, Shen MM, Dreyfus CF. J Neurosci. 2003 Jul 2;23(13):5846-53. PMID: 12843289

A novel role for retinoids in patterning the avian forebrain during presomite stages

Halilagic A, Zile MH, Studer M. Development. 2003 May;130(10):2039-50. PMID: 12668619

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development

Lagutin OV, Zhu CC, Kobayashi D, Topczewski J, Shimamura K, Puelles L, Russell HR, McKinnon PJ, Solnica-Krezel L, Oliver G. Genes Dev. 2003 Feb 1;17(3):368-79. PMID: 12569128

In vertebrate embryos, formation of anterior neural structures requires suppression of Wnt signals emanating from the paraxial mesoderm and midbrain territory. In Six3(-/-) mice, the prosencephalon was severely truncated, and the expression of Wnt1 was rostrally expanded, a finding that indicates that the mutant head was posteriorized. Ectopic expression of Six3 in chick and fish embryos, together with the use of in vivo and in vitro DNA-binding assays, allowed us to determine that Six3 is a direct negative regulator of Wnt1 expression. These results, together with those of phenotypic rescue of headless/tcf3 zebrafish mutants by mouse Six3, demonstrate that regionalization of the vertebrate forebrain involves repression of Wnt1 expression by Six3 within the anterior neuroectoderm. Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate.

Temporal sequence of gene expression leading caudal prosencephalon to develop a midbrain/hindbrain phenotype

Dev Dyn. 2002 Jan;223(1):141-7. Hidalgo-Sánchez M, Alvarado-Mallart RM.

Transplantation of prosomeres 1-2 into the cerebellar plate were used, by using chick/quail chimeras, to analyse the temporal sequence of the genetic cascade leading the graft to develop a midbrain/hindbrain phenotype. Our results show that (1) at Hamburger and Hamilton (HH) stage 13, Pax2 and En2 are already induced within the graft, before all other genes of the cascade, whereas misexpression of Fgf8 is also observed within the contiguous host cerebellar plate; (2) within the graft, Otx2 repression and Gbx2 induction (see Hidalgo-Sánchez et al. [1999] Development 126:3191-3203) are secondary events that affect, from stages HH14-15, the areas in contact with the host Gbx2/Fgf8-expressing cerebellar plate; (3) at these stages, the repressed Otx2 territory extends beyond the areas induced to express Gbx2, with the two territories not abutting before HH17-18; (4) Fgf8 expression becomes progressively induced within the Otx2-repressed/Gbx2-induced territory, starting at HH15-16. Our results support the hypothesis that the host-Gbx2/graft-Otx2 interface could trigger the genetic cascade induced within the graft and that the Gbx2-induced domain could play a key role during the establishment of the induced intragraft midbrain/hindbrain boundary.

PMID: 11803577